Kempuraj Duraisamy, Ph.D.
Co-Director, E.M. Papper Laboratory of Clinical Immunology
Associate Professor, Institute for Neuro-Immune Medicine, Nova Southeastern University
Dr. Duraisamy received his Bachelor of Science, Master of Science, Master of Philosophy, and Doctor of Philosophy from University of Madras in Chennai, India. He later was a Postdoctoral Fellow at National Children's Medical Research Center in Tokyo, Japan and at Tufts University School of Medicine in Boston, Massachusetts where he studied inflammation and immunology.
Dr. Duraisamy's research is focused on the long-term effects of neuroimmune and neurodegenerative disorders, traumatic brain injury (TBI), and stress comorbidity in Alzheimer’s disease (AD) pathogenesis and biomarkers for neuroimmune/inflammatory diseases. He has a broad background in neuroinflammation, biomarkers, brain cell culture, anti-inflammatory- natural molecules, and mast cells which spans over 20 years.
- U54 center grant - Patient subgroups, novel biomarker signatures and In vitro neuroinflammation modeling using activation of human microglia in the pathogenesis and treatment of ME/CFS MPIs: N Klimas & TC Theoharides; Key Personnel/Co-Core Lead: Kempuraj Duraisamy
- Department of Defense (DoD) “Biomarkers of neuroinflammation, brain organoid disease surrogate and use of eriodyctiol in the pathogenesis and treatment of AD” PI: Theoharides Co-I: Kempuraj Duraisamy
- Submitted VA Merit grant application entitled “Targeted Gene Therapy and Nanomedicine Approaches to Treat Corneal Diseases” PI: Rajiv R. Mohan; Key Personnel/Co-I: Kempuraj Duraisamy
- Submitted VA Merit grant application entitled “Targeted Gene Therapy and Nanomedicine Approaches to Treat Corneal Diseases” PI: Rajiv R. Mohan; Key Personnel/Co-I: Kempuraj Duraisamy.
2022
- Carbofuran pesticide toxicity to the eye Kempuraj D, Zhang E, Gupta S, Gupta RC, Sinha NR, Mohan RR. Exp Eye Res. 2022 Dec 23;227:109355. doi: 10.1016/j.exer.2022.109355. Epub ahead of print. PMID: 36572166.
- Corneal fibrosis abrogation by a localized AAV-mediated inhibitor of differentiation 3 (Id3) gene therapy in rabbit eyes in vivo Gupta S, Fink MK, Kempuraj D, Sinha NR, Martin LM, Keele LM, Sinha PR, Giuliano EA, Hesemann NP, Raikwar SP, Chaurasia SS, Mohan RR. Mol Ther. 2022 Aug 26:S1525-0016(22)00503-2. doi: 10.1016/j.ymthe.2022.08.015. Epub ahead of print. Erratum for: Mol Ther. 2022 Jul 2;: PMID: 36029769.
- Corneal stromal repair and regeneration Mohan RR, Kempuraj D, D'Souza S, Ghosh A. Prog Retin Eye Res. 2022 May 29:101090. doi: 10.1016/j.preteyeres.2022.101090. Epub ahead of print. PMID: 35649962.
- Evaluation of CRISPR/Cas9 mediated TGIF gene editing to inhibit corneal fibrosis in vitro Tripathi R, Sinha NR, Kempuraj D, Balne PK, Landreneau JR, Juneja A, Webel AD, Mohan RR. Exp Eye Res. 2022 Jul;220:109113. doi: 10.1016/j.exer.2022.109113. Epub 2022 May 16. PMID: 35588782.
- Autophagy in Extracellular Matrix and Wound Healing Modulation in the Cornea Kempuraj D, Mohan RR. Biomedicines. 2022 Feb 1;10(2):339. doi: 10.3390/biomedicines10020339. PMID: 35203548; PMCID: PMC8961790.
2021
- Immune Suppression of Glia Maturation Factor Reverses Behavioral Impairment, Attenuates Amyloid Plaque Pathology and Neuroinflammation in an Alzheimer's Disease Mouse Model Ahmed ME, Selvakumar GP, Thangavel R, Kempuraj D, Raikwar SP, Zaheer S, Iyer S, Zaheer A. J Neuroimmune Pharmacol. 2021 Jun;16(2):363-375. doi: 10.1007/s11481-020-09929-4. Epub 2020 Jun 5. PMID: 32504312; PMCID: PMC8240471.
- Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study Zafar A, Farooqui M, Ikram A, Suriya S, Kempuraj D, Khan M, Tasneem N, Qaryouti D, Quadri S, Adams HP, Ortega-Gutierrez S, Leira E, Zaheer A. Surg Neurol Int. 2021 Jul 27;12:366. doi: 10.25259/SNI_569_2021. PMID: 34513133; PMCID: PMC8422456.
- Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma Kempuraj D, Thangavel R, Kempuraj DD, Ahmed ME, Selvakumar GP, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Chandrasekaran PN, Zaheer A. Biofactors. 2021 Mar;47(2):190-197. doi: 10.1002/biof.1687. Epub 2020 Oct 24. PMID: 33098588.
- Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the Brain Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Nattanmai Chandrasekaran P, Burton C, James D, Zaheer A. Neurotox Res. 2021 Apr;39(2):359-368. doi: 10.1007/s12640-020-00288-9. Epub 2020 Sep 21. PMID: 32955722; PMCID: PMC7502806.
- Real-Time Noninvasive Bioluminescence, Ultrasound and Photoacoustic Imaging in NFκB-RE-Luc Transgenic Mice Reveal Glia Maturation Factor-Mediated Immediate and Sustained Spatio-Temporal Activation of NFκB Signaling Post-Traumatic Brain Injury in a Gender-Specific Manner Raikwar SP, Thangavel R, Ahmed ME, Selvakumar GP, Kempuraj D, Wu K, Khan O, Bazley K, Bussinger B, Kukulka K, Zaheer S, Iyer SS, Govindarajan R, Burton C, James D, Zaheer A. Cell Mol Neurobiol. 2021 Nov;41(8):1687-1706. doi: 10.1007/s10571-020-00937-9. Epub 2020 Aug 12. PMID: 32785863; PMCID: PMC8188847.
2020
- Current Trends in Biomarkers for Traumatic Brain Injury Mehta T, Fayyaz M, Giler GE, Kaur H, Raikwar SP, Kempuraj D, Selvakumar GP, Ahmed ME, Thangavel R, Zaheer S, Iyer S, Govindarajan R, Zaheer A. Open Access J Neurol Neurosurg. 2020;12(4):86-94. Epub 2020 Jan 8. PMID: 32775958; PMCID: PMC7410004.
- Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Khan A, Zaheer S, Iyer S, Burton C, James D, Zaheer A. Mol Neurobiol. 2020 Nov;57(11):4438-4450. doi: 10.1007/s12035-020-02040-y. Epub 2020 Jul 31. PMID: 32737763.
- Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Mediators Inflamm. 2020 Jun 24;2020:4243953. doi: 10.1155/2020/4243953. PMID: 32684835; PMCID: PMC7333064.
- COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation Kempuraj D, Selvakumar GP, Ahmed ME, Raikwar SP, Thangavel R, Khan A, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Neuroscientist. 2020 Oct-Dec;26(5-6):402-414. doi: 10.1177/1073858420941476. Epub 2020 Jul 18. PMID: 32684080.
- Absence of Glia Maturation Factor Protects from Axonal Injury and Motor Behavioral Impairments after Traumatic Brain Injury Selvakumar GP, Ahmed ME, Iyer SS, Thangavel R, Kempuraj D, Raikwar SP, Bazley K, Wu K, Khan A, Kukulka K, Bussinger B, Zaheer S, Burton C, James D, Zaheer A. Exp Neurobiol. 2020 Jun 30;29(3):230-248. doi: 10.5607/en20017. PMID: 32565489; PMCID: PMC7344375.
- NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease Javed H, Thangavel R, Selvakumar GP, Dubova I, Schwartz N, Ahmed ME, Zaheer S, Kempuraj D, Iyer S, Zaheer A, Khan MM. Int Immunopharmacol. 2020 Jun;83:106441. doi: 10.1016/j.intimp.2020.106441. Epub 2020 Apr 4. PMID: 32259702; PMCID: PMC7255416.
- Neuroinflammation Mediated by Glia Maturation Factor Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain Injury Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Kukulka K, Bussinger B, Dubova I, Zaheer S, Govindarajan R, Iyer S, Burton C, James D, Zaheer A. J Neurotrauma. 2020 Jul 15;37(14):1645-1655. doi: 10.1089/neu.2019.6932. Epub 2020 Apr 17. PMID: 32200671; PMCID: PMC7336883.
- Psychological Stress-Induced Immune Response and Risk of Alzheimer's Disease in Veterans from Operation Enduring Freedom and Operation Iraqi Freedom Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Clin Ther. 2020 Jun;42(6):974-982. doi: 10.1016/j.clinthera.2020.02.018. Epub 2020 Mar 14. PMID: 32184013; PMCID: PMC7308186.
- A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice Selvakumar GP, Ahmed ME, Thangavel R, Kempuraj D, Dubova I, Raikwar SP, Zaheer S, Iyer SS, Zaheer A. Brain Behav Immun. 2020 Jul;87:429-443. doi: 10.1016/j.bbi.2020.01.013. Epub 2020 Jan 23. PMID: 31982500; PMCID: PMC7316620.
- Brain Injury-Mediated Neuroinflammatory Response and Alzheimer's Disease Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Dhaliwal AS, Dubova I, Mentor S, Premkumar K, Saeed D, Zahoor H, Raikwar SP, Zaheer S, Iyer SS, Zaheer A. Neuroscientist. 2020 Apr;26(2):134-155. doi: 10.1177/1073858419848293. Epub 2019 May 16. PMID: 31092147; PMCID: PMC7274851.
Complete List of Dr. Duraisamy's published work.