Immunomodulation in GWI: The objective of this study is to determine changes in the transcriptional regulation in each of the four major subtypes of immune cells (helper T cells, cytotoxic T cells, B cells and NK cells) caused by GWI and identify the role of cell-cell communication in pathobiology of GWI.
Using Periodic Spatial Disturbance to Manipulate Cooperation in Bacteria: Determine how periodic spatial disturbances caused by physical force affects cooperation in bacteria. Our long-term goal is to develop an understanding of how to manipulate bacterial cooperation to either enhance, or reduce, microbial growth, using methods that are less prone to evolved resistance.
Genomic approach to find female-specific mechanisms of GWI: The goal of this research is to identify novel, female-specific, genomic characteristics of the development of GWI for a better understanding of the causes of disease.
Disentangling the Effects of PTSD from GWI for Improved Diagnostics and Treatments: We propose to disentangle the effects of post-traumatic stress disorder from Gulf War Illness to understand the role that post-traumatic stress plays in the symptoms and perpetuation of Gulf War illness in men. Consistent with our group’s previous work, we will model and analyze the changes in the immune and stress responses in subjects across time following a graded exercise challenge using a dynamic modeling approach.
Improving Diagnostics and Treatments for GWI Females by Accounting for the Effects of PTSD: We propose to disentangle the effects of post-traumatic stress disorder from Gulf War Illness to understand the role that post-traumatic stress plays in the symptoms and perpetuation of Gulf War illness in women. Consistent with our group’s previous work, we will model and analyze the changes in the immune and stress responses in women across time following an exercise challenge using a dynamic modeling approach.
Theory-driven Models for Correcting “Fight or Flight” Imbalance in Gulf War Illness: The goal of this project is to create a comprehensive engineering model of endocrine-immune interaction dynamics in order to (i) detect and identify theoretical failure modes of the HPA-immune axis that align with manifestations of GWI and CFS, and (ii) use computer simulations to identify promising treatment strategies that exploit the regulatory dynamics of these systems in redirecting the overall system to normal coordinated activity.
Post-exertion malaise in CFS: A systems biology approach to understanding brain, inflammation and behavior interactions: The main goal is to determine the dynamic relationships between brain structure and function, gene expression for sensory, adrenergic, and immune function and self-reported symptoms in chronic fatigue syndrome (CFS/ME) using an exercise model in a systems biology framework.