Current research efforts at the CSB lab are focused on understanding immune dysfunction and neuroinflammation from an integrated systems perspective. In particular, our group is investigating how subtle imbalances in the interplay between the immune system’s multiple components as well as its interactions with the endocrine and nervous systems may lead to complex disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Gulf War Illness (GWI), and other neurodegenerative disorders such as Alzheimer's Disease and Parkinson's Disease. Illnesses such as these continue to defy a conventional one-piece-at-a-time approach. As none of the body’s systems function in isolation, we believe that new insight can be achieved by considering the immune, endocrine and nervous systems as part of an overarching and integrated whole. This comprehensive approach is at the very heart of systems biology: an emerging science where context and interaction are key focal points.