E.M. Papper Laboratory of Clinical Immunology

The E. M. Papper Laboratory of Clinical Immunology, directed by Dr. Mary Ann Fletcher, has been associated with research and clinical care for over 30 years. With laboratory facilities at the Davie Campus of NSU and the Miami VA Medical Center, our labs are licensed clinical reference labs in the State of Florida, CLIA certified and NIH, VA and DoD funded research facilities. Current tests performed in the lab include Flow Cytometry, Natural Killer Cell Toxicity, Multiplex Cytokines and EBV viral load assays. Gene expression research and testing is also performed in the laboratory with the use of the NanoString Analyser.

In addition, the laboratory is an established biobank with emergency back-up freezers and is a long standing participant in the ACTG/Duke proficiency testing program for cryopreservation, storage and shipping of peripheral blood mononuclear cells.

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The E.M. Papper Laboratory of Clinical Immunology is an independent laboratory. Physicians may send samples to the lab for testing.

Please email EMPapper@nova.edu for a comprehensive list of lab services offered, pricing inquiries, procedure and general questions.

Sample of Laboratory Tests Offered

TEST	Description	CPT
Immunoglobulin Quantitation	IgG, IgA, IgM	82784 (x3)
Immunoglobulin Subclasses	IgG1, IgG2, IgG3, IgG4	82787 (x4)
Epstein-Barr Nuclear Antigen (EBNA)	IgG	86664
Epstein-Barr Virus Early Antigen (EB-EA)	IgG	86663
Epstein-Barr Virus (VCA)	IgG	86665
Epstein-Barr Virus (VCA)	IgM	86665
Herpes Simplex Virus-2	IgG	86696
Human Herpes Virus-6	IgG	86790 (x4)
C-Reactive Protein		86140
Mulitplex 18 Cytokines Panel	IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II	83520 (x18)
In vitro Cytokine Induction Assay, Multiplex 18	IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II	86353 (x2); 83520 (x18)
Lymphocyte Activations/Differential	CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b	88184; 88185 (x17)
ComprehensiveLymphocyte Activations/Differential & Natural Killer Cell Cytotoxicity	CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b, Lymphocyte Culture	88184; 88185 (x17); 86353 (x4)
T-Cells and T-Cell Subsets	CD45, CD3, CD4, CD8	88184; 88185 (x3)
T-Cell Subsets and NK-Cells	CD45, CD3, CD4, CD8, CD14, CD56	88184; 88185 (x5)
T-Cell Subsets and Natural Killer Cell Cytotoxicity	CD45, CD3, CD4, CD8, CD14, CD56, Lymphocyte Culture	88184; 88185 (x5); 86353 (x4)
T-Cell Subsets and B-Cells	CD45, CD3, CD4, CD8, CD14, CD19	88184; 88185(x5)
T-Cell Subsets, B-Cells and NK Cells	CD45, CD3, CD4, CD8, CD14, CD19, CD56	88184; 88185(x6)
Comprehensive T-Cell Subsets, B-Cells and Natural Killer Cell Cytotoxicity	CD45, CD3, CD4, CD8, CD14, CD19, CD56, Lymphocyte Culture	88184; 88185(x6); 86353(x4)
Neutrophil Oxidative Burst by Flow cytometry; culture	Flow Cytometry, Culture	88184; 88185; 86353
Leukocyte Adhesion Deficiency; culture	Flow Cytometry, Culture	88184; 88185; 86353
Perforin and granzymes in NK cells and T cells by flow cytometry and culture		88184; 88185 (x5)
Comprehensive Natural Killer Cell Cytotoxicity	CD3, CD45, CD14, CD56, Lymphocyte Culture	86353 (x4); 88184; 88185(x2); 86357
Complete Blood Count (CBC)		85025
Erythrocyte Sedimentation Rate (ESR)		85651

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Read the E.M. Papper Laboratory of Clinical Immunonology Privacy Statement.

You can also review our Privacy Practices in English, Spanish and Creole.

Meet Our Team

Director, Center of Excellence for Neuroinflammation Research

Theoharis C. Theoharides, B.A., M.S., MPhil, Ph.D., M.D., FAAAAI

Director, Center of Excellence for Neuroinflammation Research, NSU
Professor, Institute for Neuro-Immune Medicine

Dr. Theoharis C. Theoharides joined Nova Southeastern University (NSU) on July 1, 2022 as Professor at the Institute of Neuro-Immune Medicine, and Director of a new Center of Excellence on Neuroinflammation Research at the Clearwater campus. He has been Professor of Pharmacology and Internal Medicine and Director of Molecular Immunopharmacology & Drug Discovery, Tufts School of Medicine (1983-2022) and will remain as adjunct professor there.

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Directors, E.M. Papper Laboratory of Clinical Immunology

Kristina Aenlle, Ph.D.

Associate Director, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine

Dr. Kristina Aenlle's diverse research background has taken her from the brain to the stem cell niche of the bone, always with the focus of the endocrine system signaling and aging. Her research goal is to improve and promote healthy aging by understanding the molecular changes that are occurring during aging. Alongside Drs. Klimas and Fltecher, she examines the molecular mechanism of HPA/HPG axis disruption in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Gulf War illness (GWI).

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Kempuraj Duraisamy, Ph.D.

Co-Director, E.M. Papper Laboratory of Clinical Immunology
Associate Professor, Institute for Neuro-Immune Medicine, NSU

Dr. Duraisamy's research is focused on the long-term effects of neuroimmune and neurodegenerative disorders, traumatic brain injury (TBI), and stress comorbidity in Alzheimer’s disease (AD) pathogenesis and biomarkers for neuroimmune/inflammatory diseases. He has a broad background in neuroinflammation, biomarkers, brain cell culture, anti-inflammatory- natural molecules, and mast cells which spans over 20 years.

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Estella Sanchez Guerrero

Director - Medical Laboratory, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine

Professors

Lubov Nathanson, Ph.D.

Associate Professor, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU
Voluntary Assistant Professor, Dept. of Medicine, University of Miami Miller School of Medicine

Dr. Lubov Nathanson is an experienced, versatile and multidisciplinary trained scientist with over 20 years of work experience in basic and translational genomics and proteomics research. She has a combined expertise in bioinformatics, molecular biology, biochemistry and systems biology. As an Associate Professor for the Institute for Neuro-Immune Medicine, her work involves analysis of gene expression data of microarrays and RNA-seq experiments, analyzing systems biology including metabolic pathways and gene ontology, building gene interaction networks, creating custom pathways, and searching for upstream and downstream gene interactions.

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Rajendra Pangeni, Ph.D.

Assistant Professor of Genomics, Institute for Neuro-Immune Medicine

Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.

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Research Assistants and Associates