E.M. Papper Laboratory of Clinical Immunology
The E. M. Papper Laboratory of Clinical Immunology, directed by Dr. Mary Ann Fletcher, has been associated with research and clinical care for over 30 years. With laboratory facilities at the Davie Campus of NSU and the Miami VA Medical Center, our labs are licensed clinical reference labs in the State of Florida, CLIA certified and NIH, VA and DoD funded research facilities. Current tests performed in the lab include Flow Cytometry, Natural Killer Cell Toxicity, Multiplex Cytokines and EBV viral load assays. Gene expression research and testing is also performed in the laboratory with the use of the NanoString Analyser.
In addition, the laboratory is an established biobank with emergency back-up freezers and is a long standing participant in the ACTG/Duke proficiency testing program for cryopreservation, storage and shipping of peripheral blood mononuclear cells.
The E.M. Papper Laboratory of Clinical Immunology is an independent laboratory. Physicians may send samples to the lab for testing.
Please email EMPapper@nova.edu for a comprehensive list of lab services offered, pricing inquiries, procedure and general questions.
| TEST | Description | CPT |
|---|---|---|
|
Immunoglobulin Quantitation |
IgG, IgA, IgM | 82784 (x3) |
|
Immunoglobulin Subclasses |
IgG1, IgG2, IgG3, IgG4 | 82787 (x4) |
|
Epstein-Barr Nuclear Antigen (EBNA) |
IgG | 86664 |
|
Epstein-Barr Virus Early Antigen (EB-EA) |
IgG | 86663 |
|
Epstein-Barr Virus (VCA) |
IgG | 86665 |
|
Epstein-Barr Virus (VCA) |
IgM | 86665 |
|
Herpes Simplex Virus-2 |
IgG | 86696 |
|
Human Herpes Virus-6 |
IgG | 86790 (x4) |
|
C-Reactive Protein |
86140 | |
|
Mulitplex 18 Cytokines Panel |
IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II | 83520 (x18) |
|
In vitro Cytokine Induction Assay, Multiplex 18 |
IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II | 86353 (x2); 83520 (x18) |
|
Lymphocyte Activations/Differential |
CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b | 88184; 88185 (x17) |
|
ComprehensiveLymphocyte Activations/Differential & Natural Killer Cell Cytotoxicity |
CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b, Lymphocyte Culture | 88184; 88185 (x17); 86353 (x4) |
|
T-Cells and T-Cell Subsets |
CD45, CD3, CD4, CD8 | 88184; 88185 (x3) |
|
T-Cell Subsets and NK-Cells |
CD45, CD3, CD4, CD8, CD14, CD56 | 88184; 88185 (x5) |
|
T-Cell Subsets and Natural Killer Cell Cytotoxicity |
CD45, CD3, CD4, CD8, CD14, CD56, Lymphocyte Culture | 88184; 88185 (x5); 86353 (x4) |
|
T-Cell Subsets and B-Cells |
CD45, CD3, CD4, CD8, CD14, CD19 | 88184; 88185(x5) |
|
T-Cell Subsets, B-Cells and NK Cells |
CD45, CD3, CD4, CD8, CD14, CD19, CD56 | 88184; 88185(x6) |
|
Comprehensive T-Cell Subsets, B-Cells and Natural Killer Cell Cytotoxicity |
CD45, CD3, CD4, CD8, CD14, CD19, CD56, Lymphocyte Culture | 88184; 88185(x6); 86353(x4) |
|
Neutrophil Oxidative Burst by Flow cytometry; culture |
Flow Cytometry, Culture | 88184; 88185; 86353 |
|
Leukocyte Adhesion Deficiency; culture |
Flow Cytometry, Culture | 88184; 88185; 86353 |
|
Perforin and granzymes in NK cells and T cells by flow cytometry and culture |
88184; 88185 (x5) | |
|
Comprehensive Natural Killer Cell Cytotoxicity |
CD3, CD45, CD14, CD56, Lymphocyte Culture | 86353 (x4); 88184; 88185(x2); 86357 |
|
Complete Blood Count (CBC) |
85025 | |
|
Erythrocyte Sedimentation Rate (ESR) |
85651 |
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Meet Our Team
Theoharis C. Theoharides, B.A., M.S., MPhil, Ph.D., M.D., FAAAAI
Director, Center of Excellence for Neuroinflammation Research, NSU
Professor, Institute for Neuro-Immune Medicine
Dr. Theoharis C. Theoharides joined Nova Southeastern University (NSU) on July 1, 2022 as Professor at the Institute of Neuro-Immune Medicine, and Director of a new Center of Excellence on Neuroinflammation Research at the Clearwater campus. He has been Professor of Pharmacology and Internal Medicine and Director of Molecular Immunopharmacology & Drug Discovery, Tufts School of Medicine (1983-2022) and will remain as adjunct professor there.
Kristina Aenlle, Ph.D.
Associate Director, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine
Dr. Kristina Aenlle's diverse research background has taken her from the brain to the stem cell niche of the bone, always with the focus of the endocrine system signaling and aging. Her research goal is to improve and promote healthy aging by understanding the molecular changes that are occurring during aging. Alongside Drs. Klimas and Fltecher, she examines the molecular mechanism of HPA/HPG axis disruption in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Gulf War illness (GWI).
Kempuraj Duraisamy, Ph.D.
Co-Director, E.M. Papper Laboratory of Clinical Immunology
Associate Professor, Institute for Neuro-Immune Medicine, NSU
Dr. Duraisamy's research is focused on the long-term effects of neuroimmune and neurodegenerative disorders, traumatic brain injury (TBI), and stress comorbidity in Alzheimer’s disease (AD) pathogenesis and biomarkers for neuroimmune/inflammatory diseases. He has a broad background in neuroinflammation, biomarkers, brain cell culture, anti-inflammatory- natural molecules, and mast cells which spans over 20 years.
Estella Sanchez Guerrero
Director - Medical Laboratory, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine
Lubov Nathanson, Ph.D.
Associate Professor, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU
Voluntary Assistant Professor, Dept. of Medicine, University of Miami Miller School of Medicine
Dr. Lubov Nathanson is an experienced, versatile and multidisciplinary trained scientist with over 20 years of work experience in basic and translational genomics and proteomics research. She has a combined expertise in bioinformatics, molecular biology, biochemistry and systems biology. As an Associate Professor for the Institute for Neuro-Immune Medicine, her work involves analysis of gene expression data of microarrays and RNA-seq experiments, analyzing systems biology including metabolic pathways and gene ontology, building gene interaction networks, creating custom pathways, and searching for upstream and downstream gene interactions.
Rajendra Pangeni, Ph.D.
Assistant Professor of Genomics, Institute for Neuro-Immune Medicine
Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.
Research Assistants
- Tristan Anderson, Laboratory Research Assistant I
- Alina Fernandez, Laboratory Research Assistant III
- Sara Sosa Garcia, Laboratory Research Assistant II
- Dylan Isler, Laboratory Research Assistant III
Research Associates
- Axel Lilzo, Research Associate I