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Kristina Aenlle, Ph.D.

Kristina headshotAssociate Director, E.M. Papper Laboratory of Clinical Immunology

Assistant Professor, K. Patel College of Osteopathic Medicine

Dr. Kristina Aenlle diverse research background has taken her from the brain to the stem cell niche of the bone, always with the focus of the endocrine system signaling and aging. Her research goal is to improve and promote healthy aging by understanding the molecular changes that are occurring during aging. Alongside Drs. Klimas and Fltecher, she examines the molecular mechanism of HPA/HPG axis disruption in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Gulf War illness (GWI). 

Dr. Aenlle's training in endocrinology, neuroscience, aging, and biochemistry provides a strong backbone upon which she can explore the molecular and endocrine disruptions underlying ME/CFS and GWI. Her expertise contributes to the growing field of these complex, neuroinflammatory illnesses, while focusing on aging. Dr. Aenlle's long term goal is to develop a safe and efficient treatment to reboot the HPA/HPG axis and provide support during the aging process in ME/CFS and GWI.  

  • A Randomized, Double-blind Placebo-controlled Phase III Trial of Coenzyme Q10 in Gulf War Illness
  • The objectives of the proposed study are to determine the efficacy and safety of ubiquinol in men and women suffering from Gulf War Illness. This study will also offer a platform for the much needed analysis of outcome variables in a well characterized longitudinal cohort; both biomarkers and clinical measures will be analyzed for their utility in future studies.
  • Measurement of Biomarkers in Samples Collected in a Coenzyme Q10 Treatment Trial in Gulf War Illness and Control Subjects
  • The primary objective is of DoD Gulf War Illness Clinical Partnership Award is to determine the efficacy of CoQ10 in GWI related symptom control.
  • Immune/Inflammatory Priming in Exacerbating Responses to GWVI Stressors: Implications for GWVI Treatments
  • The collaborative MERIT proposal hypothesizes that hyperinflammatory profiles in Gulf War Veterans could be due to exposures to chemical and/or environmental stressor and multiple vaccinations experienced by Veterans during the Gulf War, which sensitizes the affected veterans to the development of Gulf War Veterans Illness. The present project is designed in both rodent models and veterans’ cohort to test the hypothesis that chemical stressors, like insecticides and nerve gas antidotes routinely used during deployment, may induce gastrointestinal dysbiosis (gut microbiome changes) and metabolomic alterations via modulations of the gut inflammasome. These microbiome changes may lead to disruptions in barrier functions thus allowing continuous penetration of endotoxin/inflammatory mediators into the brain. These events may ultimately induce a sustained hyperinflammatory state while inflammasome blockers/probiotics may attenuate the above responses by blocking dysbiosis.

Peer-Reviewed Publications

  • A common language for Gulf War Illness (GWI) research studies: GWI common data elements
  • Cohen DE, Sullivan KA, McNeil RB, Klimas NG; Gulf War Illness Common Data Elements Working Group; Symptoms Assessment Working Group, McNeil R, Ashford W, Bested A, Bunker J, Cheema A, Cohen D, Cook D, Cournoyer J, Craddock T, Golier J, Hardie A, Helmer D, Lindheimer JB, Lloyd PJ, Kerr K, Krengel M, Nadkarni S, Nugent S, Paris B, Reinhard M, Rumm P, Schneiderman A, Sims KJ, Steele L, Turner M; Systems Assessment Working Group, Sullivan K, Abdullah L, Abreu M, Abu-Donia M, Aenlle K, Arocho J, Balbin E, Baraniuk J, Block K, Block M, DeBeer B, Engdahl B, Filipov N, Fletcher MA, Kalasinsky V, Kokkotou E, Lidie K, Little D, Loging W, Morris M, Nathanson L, Nichols MD, Pasinetti G, Shungu D, Waziry P, VanLeeuwen J, Younger J; GWI CDE Administrative Team, Klimas N. Life Sci. 2021 Aug 2:119818. doi: 10.1016/j.lfs.2021.119818. PMID: 34352259.
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