The E. M. Papper Laboratory of Clinical Immunology, directed by Dr. Kristina Aenlle, has been at the forefront of research and clinical care for over 30 years. With laboratory facilities at Nova Southeastern University’s Fort Lauderdale/Davie Campus and the Miami VA Medical Center, our laboratories are licensed clinical reference labs in the State of Florida, CLIA-certified, and National Institutes of Health (NIH), U.S. Department of Veterans Affairs (VA), and Department of Defense-funded research facilities.
Pioneering Neuro-Immune Research
The E.M. Papper Laboratory is a testament to the pioneering work and unwavering dedication of Dr. Mary Ann Fletcher, its former director. As the inaugural Schemel Professor for Neuro-Immune Medicine at the Dr. Kiran C. Patel College of Osteopathic Medicine, Dr. Fletcher's contributions to the field of immunology and infectious diseases have been widely recognized.
Her extensive research, which spanned decades at the University of Miami and the Institute for Neuro-Immune Medicine at NSU, focused on proteomic and genomic studies. The E.M. Papper Laboratory, a legacy of her tenure at Miami, continues to be a cornerstone of research excellence.
Laboratory Services
NSU’s E.M. Papper Laboratory of Clinical Immunology is an independent lab and offers a range of diagnostic tests, including:
- Flow Cytometry
- Natural Killer Cell Toxicity
- Multiplex Cytokines
- EBV Viral Load Assays
We also conduct gene expression research using the NanoString Analyser.
Physicians may send samples to the lab for testing. For a comprehensive list of lab services, pricing inquiries, procedures, and general questions, please email EMPapper@nova.edu.
|
Test |
Description |
CPT |
|---|---|---|
|
Immunoglobulin Quantitation |
IgG, IgA, IgM |
82784 (x3) |
|
Immunoglobulin Subclasses |
IgG1, IgG2, IgG3, IgG4 |
82787 (x4) |
|
Epstein-Barr Nuclear Antigen (EBNA) |
IgG |
86664 |
|
Epstein-Barr Virus Early Antigen (EB-EA) |
IgG |
86663 |
|
Epstein-Barr Virus (VCA) |
IgG |
86665 |
|
Epstein-Barr Virus (VCA) |
IgM |
86665 |
|
Herpes Simplex Virus-2 |
IgG |
86696 |
|
Human Herpes Virus-6 |
IgG |
86790 (x4) |
|
C-Reactive Protein |
86140 |
|
|
Mulitplex 18 Cytokines Panel |
IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II |
83520 (x18) |
|
In vitro Cytokine Induction Assay, Multiplex 18 |
IL-1a, IL-1b IL-4, IL-8, IL-13, IL-23, IL-5, IL-10, IL-15, IL-2, IL-6, IL-12, IL-17, Tumor Necrosis Factor α, Tumor Necrosis Factor β, Interferon Gamma (IFNy), TNF Receptor I, TNF Receptor II |
86353 (x2); 83520 (x18) |
|
Lymphocyte Activations/Differential |
CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b |
88184; 88185 (x17) |
|
Comprehensive Lymphocyte Activations/Differential & Natural Killer Cell Cytotoxicity |
CD45, CD3, CD4, CD8, CD5, CD2, CD45RA, CD26, CD56, CD38, CD19, CD95, CD25, CD28, CD14, CD62L, CD11a, CD11b, Lymphocyte Culture |
88184; 88185 (x17); 86353 (x4) |
|
T-Cells and T-Cell Subsets |
CD45, CD3, CD4, CD8 |
88184; 88185 (x3) |
|
T-Cell Subsets and NK-Cells |
CD45, CD3, CD4, CD8, CD14, CD56 |
88184; 88185 (x5) |
|
T-Cell Subsets and Natural Killer Cell Cytotoxicity |
CD45, CD3, CD4, CD8, CD14, CD56, Lymphocyte Culture |
88184; 88185 (x5); 86353 (x4) |
|
T-Cell Subsets and B-Cells |
CD45, CD3, CD4, CD8, CD14, CD19 |
88184; 88185(x5) |
|
T-Cell Subsets, B-Cells and NK Cells |
CD45, CD3, CD4, CD8, CD14, CD19, CD56 |
88184; 88185(x6) |
|
Comprehensive T-Cell Subsets, B-Cells and Natural Killer Cell Cytotoxicity |
CD45, CD3, CD4, CD8, CD14, CD19, CD56, Lymphocyte Culture |
88184; 88185(x6); 86353(x4) |
|
Neutrophil Oxidative Burst by Flow cytometry; culture |
Flow Cytometry, Culture |
88184; 88185; 86353 |
|
Leukocyte Adhesion Deficiency; culture |
Flow Cytometry, Culture |
88184; 88185; 86353 |
|
Perforin and granzymes in NK cells and T cells by flow cytometry and culture |
88184; 88185 (x5) |
|
|
Comprehensive Natural Killer Cell Cytotoxicity |
CD3, CD45, CD14, CD56, Lymphocyte Culture |
86353 (x4); 88184; 88185(x2); 86357 |
|
Complete Blood Count (CBC) |
85025 |
|
|
Erythrocyte Sedimentation Rate (ESR) |
85651 |
BioBank and Proficiency Testing Program
The E.M. Papper Laboratory also houses a biobank with emergency backup freezers and participates in the ACTG/Duke proficiency testing program, ensuring quality in the cryopreservation, storage, and shipment of blood samples.
Ensuring Patient Privacy
We are committed to protecting patient information. Providers can review our Privacy Statement (PDF) and access our Privacy Practices in English (PDF), Spanish (PDF) and Creole (PDF) for compliance.
Meet Our Team of Experts
Nancy G. Klimas, M.D.
Director, Institute for Neuro-Immune Medicine, NSU
Professor and Chair, Department of Clinical Immunology, NSU
Assistant Dean of Research, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU
Director, Environmental Medicine Research and Clinical Program Miami VA Medical Center
Professor Emerita, University of Miami, School of Medicine
Dr. Nancy Klimas has 40 years of professional experience and has achieved international recognition for her research and clinical efforts in multi-symptom disorders, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Gulf War illness (GWI), fibromyalgia, and most recently Long COVID.
Kristina Aenlle, Ph.D.
Associate Director, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine
Dr. Kristina Aenlle's diverse research background has taken her from the brain to the stem cell niche of the bone, always with the focus of the endocrine system signaling and aging. Her research goal is to improve and promote healthy aging by understanding the molecular changes that are occurring during aging. Alongside Drs. Klimas and Fltecher, she examines the molecular mechanism of HPA/HPG axis disruption in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Gulf War illness (GWI).
Enriqueta Molinares
Research Lab Manager, E.M. Papper Laboratory of Clinical Immunology
Estella Sanchez Guerrero, Ph.D. and MDT
Director - Medical Laboratory, E.M. Papper Laboratory of Clinical Immunology
Assistant Professor, Dr. Kiran C. Patel College of Osteopathic Medicine
Lubov Nathanson, Ph.D.
Associate Professor, Dr. Kiran C. Patel College of Osteopathic Medicine, NSU
Voluntary Assistant Professor, Dept. of Medicine, University of Miami Miller School
of Medicine
Dr. Lubov Nathanson is an experienced, versatile and multidisciplinary trained scientist with over 20 years of work experience in basic and translational genomics and proteomics research. She has a combined expertise in bioinformatics, molecular biology, biochemistry and systems biology. As an Associate Professor for the Institute for Neuro-Immune Medicine, her work involves analysis of gene expression data of microarrays and RNA-seq experiments, analyzing systems biology including metabolic pathways and gene ontology, building gene interaction networks, creating custom pathways, and searching for upstream and downstream gene interactions.
Rajendra Pangeni, Ph.D.
Assistant Professor of Genomics, Institute for Neuro-Immune Medicine
Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.
Rajendra Pangeni, Ph.D.
Assistant Professor of Genomics, Institute for Neuro-Immune Medicine
Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.
Rajendra Pangeni, Ph.D.
Assistant Professor of Genomics, Institute for Neuro-Immune Medicine
Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.
Rajendra Pangeni, Ph.D.
Assistant Professor of Genomics, Institute for Neuro-Immune Medicine
Dr. Rajendra Pangeni, completed his PhD in molecular oncology from the University of Wolverhampton, UK. During his PhD, he worked on DNA methylation dysregulation in breast cancer metastases to the brain using genome wide and laboratory approaches. He received his post-doctoral trainings from Northwestern University Chicago and City of Hope National Medical Center, Duarte, California. During his post doctoral works, Dr. Pangeni worked on glioblastoma (one of the most aggressive brain tumors) and non-small cell lung cancer using genome wide DNA methylation array, RNA sequencing, stem cells, mouse models, and other genetic and epigenetics approaches.
Research Assistants
- Tristan Anderson, Laboratory Research Assistant I
- Alina Fernandez, Laboratory Research Assistant III
- Sara Sosa Garcia, Laboratory Research Assistant II
- Dylan Isler, Laboratory Research Assistant III
Research Associates
- Axel Lilzo, Research Associate I
- Luis Salgueiro, Ph.D., Research Associate | Read bio
Sandra Yudice, Administrative Assistant II
Get in Touch
Fort Lauderdale/Davie
Center for Collaborative Research, 4th Floor
7595 SW 33rd Street
Fort Lauderdale, FL 33314
Kendall
Kendall Village Center, Professional Arts Bldg., Suite 111
8501 SW 124th Avenue
Miami, FL 33183
Phone Number: (954) 262-2850
Office Hours: Monday - Friday, 9:00 a.m. - 5:00 p.m.
Connect with INIM on Social
For more information on becoming a donor or joining our newsletter, please email mcarr1@nova.edu.
