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Theoharis C. Theoharides, M.S., M.Phil., Ph.D., M.D., Ph.D., FAAAAI

Executive Director, Center of Excellence for Neuroinflammation Research (CENIR), Nova Southeastern University

Professor, Institute for Neuro-Immune Medicine 

Dr. Theoharides is Professor and Vice Chair of Clinical Immunology and Executive Director, Institute for Neuro-Immune Medicine-Clearwater, Nova Southeastern University, FL and Adjunct Professor of Immunology, at Tufts School of Medicine where he was Professor and Director of Molecular Immunopharmacology & Drug Discovery, and Clinical Pharmacologist, Massachusetts Drug Formulary Commission (1983-2022). He served on the Board of the Institute of Pharmaceutical Research and Technology (IFET) and the Supreme Health Council of the Ministry of Health in Greece. He received his BA, MS, MPhil, PhD and MD degrees and the Winternitz Price in Pathology from Yale University. He also received a Certificate in Global Leadership from Tufts Fletcher School of Law and Diplomacy and a Fellowship at Harvard Kennedy School of Government. He trained in Internal Medicine specialty at New England Medical Center which awarded him the Oliver Smith Award “recognizing excellence, compassion and service.” He received the Tufts Alumni Service Award, as well as the Tufts Distinguished Faculty Recognition and Excellence in Teaching awards multiple times. He has trained more than 200 hundred undergraduate, graduate, medical students and post-doctoral fellows.

He has been studying the regulation of mast cells and microglia, as well as their role in neuroinflammatory diseases for over 30 years. Specifically, his research is focused on the mechanism of secretion of cytokines and pro-inflammatory molecules from mast cells and microglia in response to environmental, pathogenic, stress and toxic triggers, as well as their regulation by natural flavonoid molecules. He has expertise in allergic reactions, biology of mast cells, neuroinflammation and pharmacology. His studies has been funded by NIH, DoD and private foundations and companies. He has 493 publications (48,510 citations; h-index 113 placing him in the world’s top 0.05% of most cited authors and the worldwide expert on mast cells by ScholarGPS and Expertscape. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame and the World Academy of Sciences. He developed novel dietary flavonoid supplements formulated in olive pomace oil to increase absorption. He has received 30 patents and trademarks. He is an expert in neuroinflammatory diseases and was awarded U.S. Patent # 8,268,365 for “Anti-inflammatory compositions for treating brain inflammation."

Visit Dr. Theoharides' personal website, Mast Cell Master and https://www.drtheoharides.com/. 

Anonymous donation
Theoharides (PI) 1/1/21-12/31/2023
Neuroimmune priming of human mast cells


BioTechne
Theoharides (PI) 1/1/19-8/30/2021
Effect of IL-38 on human microglia activation


Solve ME/CFS Initiative 2018 Ramsay Award
Theoharides (PI) 11/1/18-12/31/2019
Role of extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Podcast: Pelvic Health Support
Episode Title: Unlocking the Connection Between IC/BPS & Vulvodynia with Dr. Theoharis Theoharides, M.D., Ph.D.
Link: https://www.youtube.com/watch?v=EjyIpEFau88&t=987s
Description: In this eye-opening interview, the renowned Dr. Theoharides, a leading expert in neuroinflammation and mast cells, discusses the link between these chronic pain conditions, and how they can be effectively managed.

 

Podcast: The Smartest Doctor in the Room
Episode Title: Ep.155 - Mastering Mast Cell Mysteries: The Surprising Link Between Allergies, Long COVID, and Brain Health.
Link: https://podcasts.apple.com/us/podcast/the-smartest-doctor-in-the-room/id1612081247?i=1000676624011
Description: In this episode of The Smartest Doctor in the Room podcast, Dr. Dean Mitchell is joined by Dr. Theoharis Theoharides. They uncover the hidden power of mast cells—cells once thought to only trigger allergies but now linked to long COVID, chronic fatigue, neurological symptoms, and more.


Brain Fog: Causes and Prevention



Inflammation Derails Brain Homeostasis



Mast Cell Over-Activation, and How It Affects Our Mind and Body Wellbeing



Interstitial Cystitis: Diagnosis and Treatment



Demystifying Mast Cells: How To Get The Right Diagnosis



My mystery symptoms and mast cells

Mast cells and autism


Role of Mast Cells in Inflammation of the Brain and Autism Spectrum Disorder 


Dr Theoharides speaks at the 9-2023 NIH workshop on Neurologic Aspects of Long-COVID On SARS-CoV-2 spike protein, neuroinflammation and brain fog. 


The Role of Mast Cells & Histamine in Interstitial Cystitis 


IIMEC13 Anne Örtegren Memorial Lecture Professor Theoharis C Theoharides 


Dr. Theoharides Sensitive Children 



Live Webinar-Autism Research Coalition

Get an MCAS Diagnosis with These question

2025
  • Tsilioni I, Duraisami K, Theoharides TC. Nobiletin and Eriodictyol Suppress Release of IL-1β, CXCL8, IL-6 and MMP-9 from LPS, SARS-CoV-2 Spike protein and Ochratoxin A-Stimulated Human Microglia. Intl J Mol Sci, 2025. n press.
2024
  • Demopoulos CA, Antonopoulou S, Theoharides TC. Is Platelet-Activating Factor the Missing Link Between COVID-19 and Atherosclerosis? JACC Adv. 2024 Nov 9;3(12):101397

2023

 

2022
 
2021
  • Neurohormonal markers in chronic rhinosinusitis
    • Compton RA, Lonergan AR, Tsillioni I, Conti P, Ronconi G, Lauritano D, Rebeiz EE, Theoharides TC. J Biol Regul Homeost Agents. 2021 May-Jun;35(3):901-908. doi: 10.23812/21-35-3-E2. PMID: 34231347.
  • Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference
    • Gotlib J, George TI, Carter MC, Austen KF, Bochner B, Dwyer DF, Lyons JJ, Hamilton MJ, Butterfield J, Bonadonna P, Weiler C, Galli SJ, Schwartz LB, Elberink HO, Maitland A, Theoharides T, Ustun C, Horny HP, Orfao A, Deininger M, Radia D, Jawhar M, Kluin-Nelemans H, Metcalfe DD, Arock M, Sperr WR, Valent P, Castells M, Akin C. J Allergy Clin Immunol. 2021 Jun;147(6):2043-2052. doi: 10.1016/j.jaci.2021.03.008. Epub 2021 Mar 11. PMID: 33745886.
 
2020

 

Complete List of Dr. Theoharides' published work.

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