Director, Center of Excellence for Neuroinflammation Research, Nova Southeastern University
Professor, Institute for Neuro-Immune Medicine
Dr. Theoharis C. Theoharides joined Nova Southeastern University (NSU) on July 1, 2022 as Professor at the Institute of Neuro-Immune Medicine, and Director of a new Center of Excellence on Neuroinflammation Research at the Clearwater campus. He has been Professor of Pharmacology and Internal Medicine and Director of Molecular Immunopharmacology & Drug Discovery, Tufts School of Medicine (1983-2022) and will remain as Adjunct Professor there.
Dr. Theoharides received his Bachelor of Art, Master of Science, Master of Philosophy, Doctor of Philosophy, and Doctor of Medicine from Yale University and was awarded the Winternitz Price in Pathology. He trained in internal medicine at New England Medical Center and received the Oliver Smith Award “recognizing excellence, compassion and service.” He was awarded the Tufts Distinguished Faculty Recognition and Excellence in Teaching Awards multiple times, as well as the Alumni Excellence in Service Award. He also received a Certificate in Global Leadership from the Tufts Fletcher School of Law and Diplomacy and a Fellowship at the Harvard Kennedy School of Government. He first showed that the unique tissue immune cells, mast cells, play a key role in the pathogenesis of in autism spectrum disorder, as well as in other conditions that involve neuroinflammation such as chronic fatigue syndrome and Long-COVID syndrome.
Dr. Theoharides has over 486 publications with 46,491 citations placing him in the world’s top 2% of most cited authors and he is the top-rated expert on mast cells by Expertscape. He has received 37 patents and trademarks. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame and the World Academy of Sciences. He also received the 2018 Who Is Who Lifetime Achievement Award and the Distinguished Humanitarian Award. Dr. Theoharides has also helped develop some unique supplements containing flavonoids (www.algonot.com).
Visit Dr. Theoharides' personal website, Mast Cell Master.
Anonymous donation
Theoharides (PI) 1/1/21-12/31/2023
Neuroimmune priming of human mast cells
BioTechne
Theoharides (PI) 1/1/19-8/30/2021
Effect of IL-38 on human microglia activation
Solve ME/CFS Initiative 2018 Ramsay Award
Theoharides (PI) 11/1/18-12/31/2019
Role of extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Molecular Profiling of the Hippocampus of Children with Autism Spectrum Disorder.
Rexrode L, Hartley J, Showmaker KC, Vandewege MW, Martin BE, Blair E, Bollavarapu R, Antonyraj RB, Hilton K, Gardiner A, Valeri J, Gisabella B, Garrett M, Theoharides TC, Pantazopoulos H. Molecular Psychiatry. 2024, in Press.
Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation.
Theoharides TC, Twahir A, Kempuraj D. Ann Allergy Asthma Immunol. 2023 Nov 10:S1081-1206(23)01397-2. doi: 10.1016/j.anai.2023.10.032. Online ahead of print.PMID: 37951572
COVID-19 and Long COVID: Disruption of the Neurovascular Unit, Blood-Brain Barrier, and Tight Junctions.
Kempuraj D, Aenlle KK, Cohen J, Mathew A, Isler D, Pangeni RP, Nathanson L, Theoharides TC, Klimas NG. Neuroscientist. 2023 Sep 11:10738584231194927. doi: 10.1177/10738584231194927. Online ahead of print.PMID: 37694571 Review.
The Role of Mast Cells and Their Inflammatory Mediators in Immunity.
Theoharides TC. Int J Mol Sci. 2023 Jul 28;24(15):12130. doi: 10.3390/ijms241512130.PMID: 37569506
Potential Role of Moesin in Regulating Mast Cell Secretion.
Theoharides TC, Kempuraj D. Int J Mol Sci. 2023 Jul 28;24(15):12081. doi: 10.3390/ijms241512081.PMID: 37569454
Recombinant SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Stimulate Release of Different Pro-Inflammatory Mediators via Activation of Distinct Receptors on Human Microglia Cells.
Tsilioni I, Theoharides TC. Mol Neurobiol. 2023 Nov;60(11):6704-6714. doi: 10.1007/s12035-023-03493-7. Epub 2023 Jul 21.PMID: 37477768
Recombinant SARS-CoV-2 Spike Protein Stimulates Secretion of Chymase, Tryptase, and IL-1β from Human Mast Cells, Augmented by IL-33.
Tsilioni I, Theoharides TC. Int J Mol Sci. 2023 May 30;24(11):9487. doi: 10.3390/ijms24119487.PMID: 37298438
Humoral Innate Immunity and Acute-Phase Proteins.
Theoharides TC, Tsilioni I. N Engl J Med. 2023 May 4;388(18):1725. doi: 10.1056/NEJMc2302460.PMID: 37133604 No abstract available.
Mast cell activation: beyond histamine and tryptase.
Theoharides TC, Perlman AI, Twahir A, Kempuraj D. Expert Rev Clin Immunol. 2023 Jun;19(6):639-654. doi: 10.1080/1744666X.2023.2200936. Epub 2023 Apr 14.PMID: 37029958
Role of SARS-CoV-2 Spike-Protein-Induced Activation of Microglia and Mast Cells in the Pathogenesis of Neuro-COVID.
Theoharides TC, Kempuraj D. Cells. 2023 Feb 22;12(5):688. doi: 10.3390/cells12050688.PMID: 36899824
Complete List of Dr. Theoharides' published work.
My mystery symptoms and mast cells
Role of Mast Cells in Inflammation of the Brain and Autism Spectrum Disorder
Dr Theoharides speaks at the 9-2023 NIH workshop on Neurologic Aspects of Long-COVID On SARS-CoV-2 spike protein, neuroinflammation and brain fog.
The Role of Mast Cells & Histamine in Interstitial Cystitis
IIMEC13 Anne Örtegren Memorial Lecture Professor Theoharis C Theoharides
Dr. Theoharides Sensitive Children
Live Webinar-Autism Research Coalition