017-21 NSU TRED Annual Report FY2021_Web

Annual Report | Fiscal Year 2021 Alexander V. Soloviev, Ph.D. Halmos College of Arts and Sciences FY 2021 Provost’s Research and Scholarship Award Winner NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT

Senior Vice President’s Message ...................................... 2 Vice President’s Message................................................... 3 Research Administration.................................................... 4 Research Sta ...................................................................... 5 Research Spotlights ............................................................ 6 Centers for Disease Control and Prevention Fund $4.4M Post-COVID Study at NSU .................... 7 National Science Foundation Funds for Interdisciplinary Graduate Research Program in Coral Reef Science................................................... 8 Student Spotlights ............................................................ 10 NSU Core Facilities ............................................................. 12 NSU Technologies ..............................................................14 Sponsored Funding by The Numbers—FY 2021 ............ 15 Higher Education Research and Development Expenditures at Private Institutions................................ 15 Funding Agencies—FY 2021 .............................................16 Research Metrics—FY 2021 ............................................... 17 Overview and Highlights ...........................................19 President’s Faculty Research and Development Grant Program........................... 23 Quality of Life Program ............................................ 25 NSU Clinical Research ............................................... 26 NSU Technology Transfer and Commercialization............................................. 27 Contact Us .......................................................................... 29 TABLE OF CONTENTS Accreditation Nova Southeastern University is accredited by the Southern Association of Colleges and Schools Commission on Colleges to award associate’s, baccalaureate, master’s, educational specialist, doctorate, and professional degrees. Contact the Commission on Colleges at 1866 Southern Lane, Decatur, Georgia 30033-4097 or call 404-679-4500 for questions about the accreditation of Nova Southeastern University. Notice of Nondiscrimination Nova Southeastern University admits students of any race, color, sex, age, nondisqualifying disability, religion or creed, sexual orientation, gender, gender identity, military service, veteran status, or national or ethnic origin to all the rights, privileges, programs, and activities generally accorded or made available to students at the school, and does not discriminate in administration of its educational policies, admissions policies, scholarship and loan programs, and athletic and other school-administered programs. Any such acts are unacceptable and strictly prohibited by the university.

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 1

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 2 As we launch a new fiscal year, Nova Southeastern University’s (NSU’s) research enterprise is in a period of transition and growth. On September 1, 2021, I joined NSU as senior vice president for research and associate provost. By combining these two roles, I will bridge the academic and research opportunities at NSU to advance both faculty and student research and scholarship. I am very excited to be joining NSU at this critical period in its growth. The strategic expansion of basic, applied, clinical, and commercial research has elevated NSU’s position as a rising research university. The fundamentals of a strong reputation in research excellence are supported by assets like the new HCA Florida University Hospital, NSU’s premier research facilities, innovative research, highly qualified faculty, and all the students who are advancing their lives and careers through NSU. My role, along with my talented team, is to amplify ongoing initiatives and build a recognized brand of research in the state of Florida. This will be accomplished by enhancing the student experience with research across the curricula, driving and facilitating faculty research across all colleges, and leveraging NSU research as the innovation engine for economic development across the state and nationally. In close collaboration with the leadership, deans, and the research community at NSU, we will aim to further enhance grant funding toward achieving President Hanbury’s Vision 2025, increase undergraduate and graduate student research across all colleges and campuses at the university, and support a rise in innovation toward further economic development in our region. We also want to o er to our faculty and students improved infrastructure and resources to enhance their ability to do cutting-edge research, as well as to fund and disseminate their research to the world. Our division is committed to facilitating collaboration among all units across the campuses toward a one NSU for research. Ken Dawson-Scully, Ph.D., M.Sc. Senior Vice President for Research Associate Provost SENIOR VICE PRESIDENT’S MESSAGE

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 3 Each year, I feel privileged to work with Nova Southeastern University’s (NSU’s) central research department sta , whose expertise, experience, resources, and continued e orts support the ambitious research endeavors of our faculty, students, and other research professionals. Translational Research and Economic Development (TRED) is a diverse group of o ces, along with a core center of research facilities, that facilitates and enriches the research of both junior and senior investigators. We are engaged in proposal development, grant management, research compliance, capacity building, networking, and technology transfer. Our accomplishments are realized through and amplified by the scholarship and other successes of our scientists, engineers, humanists, and artists as well as our business, law, and medical professionals and other academicians. We continually evaluate and improve our services for the entire NSU research community. Our 2020–2021 fiscal year included some notable achievements and improvements to our service o erings. In addition to these enhancements, we continue to provide state-of-the-art research facilities and support through our Center for Collaborative Research (CCR) Core Research Facilities, accessible to all NSU investigators. These fee-for-service labs include flow cytometry, imaging, genomics and bioinformatics, cell therapy, and a vivarium. We have additional o ces for those engaged in research with implications beyond the lab. Our O ce of Clinical Research supports faculty conducting clinical trials, whose work aims to improve the quality of health care. Additionally, the O ce of Technology Transfer identifies and helps researchers negotiate the protection and commercialization of their intellectual and technological inventions. Current and prospective grant seekers engage with two additional units in our department: the O ce of Sponsored Programs and the Grant Writing Laboratory. The O ce of Sponsored Programs provides all the tools and support NSU faculty need to apply for, and manage, both internally- and externally-funded projects. The Grant Writing Laboratory provides research development support to assist in project ideation, finding funding, and grantsmanship as well as providing opportunities for researchers to interact and develop new collaborations. We are all committed to and motivated by the NSU research community, and look forward to leveraging past successes and seizing future opportunities to further build our institution’s research stature. Gary S. Margules, Sc.D. Vice President for Research VICE PRESIDENT’S MESSAGE

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 4 Ken Dawson-Scully, Ph.D., M.Sc. Senior Vice President for Research Associate Provost dawsonscully@nova.edu Cathy Harlan, M.P.A., CRA, GPC Director, O ce of Sponsored Programs osp@nova.edu Roxana Ross, Ed.D., M.B.A., GPC Assistant Vice President for Research rr877@nova.edu Junko Kazumi, Ph.D. Director, O ce of Technology Transfer and Commercialization jkazumi@nova.edu RESEARCH ADMINISTRATION Katherine Rose, J.D., LL.M. Associate Counsel, O ce of Translational Research and Economic Development Assistant Vice President, O ce of Research and Technology Transfer krose@nova.edu Susan Breno Manager, Clinical Research sb1382@nova.edu Gary S. Margules, Sc.D. Vice President for Research margules@nova.edu Robin Krueger, Ph.D. Scientific Director, Research Facilities rkrueger1@nova.edu

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 5 Translational Research and Economic Development Janice Roldan, M.B.A., Research Compliance Manager Wendy Gorden, Executive Assistant Center for Collaborative Research Bojie Dai, Ph.D., Genomics Core Manager Morgan Allerton-Minnis, B.S., Genomics Core Technician Dominique Ouimet, B.A., RLAT-G, RVT, Vivarium Core Manager Megan Nohelty, B.S., Vivarium Core Technician Robin Krueger, Ph.D., Cell Therapy Core Manager Solly-Ann Barton-Case, B.S., Cell Therapy Core Laboratory Specialist Kimberley Kusser, B.S., Flow Cytometry and Imaging Core Manager Awilda Ortiz, Administrative Assistant II O ce of Sponsored Programs Ashley Whitaker, Ed.D., CRA, Associate Director Alexa Gomez-Houghton, M.B.A., Contract Manager Sarah de Flesco, J.D., M.A., Assistant Director Veronica Delgado, M.P.A., Senior Grant O cer Madeline Eaton, M.P.S., B.A., Grant O cer—Internal Programs Estibalitz Igartua-Vazquez, M.B.A., Grant O cer Magalie Thomas, M.B.A., Grant O cer Erin Komak, M.S., Grant Program Coordinator Grant Writing Laboratory Melanie Bauer, M.A., Grant Writing Manager O ce of Technology Transfer and Commercialization Arunodoy Sur, Ph.D., Technology Licensing O cer RESEARCH STAFF

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 6 More than 10 percent of individuals with acute COVID-19 (SARS-CoV-2) infection continue to experience poorly understood debilitating symptoms, including fatigue and cognitive and functional impairments similar to those observed in other postinfectious fatiguing illnesses. A large research team at NSU, led by Nancy Klimas, M.D., and spanning the Institute for Neuro-Immune Medicine and the Dr. Kiran C. Patel College of Osteopathic Medicine, along with collaborators at the Centers for Disease Control and Prevention (CDC), will characterize these post-COVID conditions and factors associated with the disease. The work is supported by a $4.4M grant awarded in September 2020 by the CDC. Current study activities involve participant recruitment through local health systems and physician practices in Broward and Miami-Dade counties. The team is actively working with CDC partners and has developed a research design that continues to be responsive to updated insights that impact care for patients who continue to experience symptoms after testing positive for COVID-19. CENTERS FOR DISEASE CONTRO FUND $4.4M POST-COVID STUDY RESEARCH SPOTLIGHTS

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 7 OL AND PREVENTION Y AT NSU

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 8 Lauren Nadler, Ph.D., principal investigator (PI) and Tyler Cyronak, Ph.D., (co-PI) from Halmos College of Arts and Science’s Department of Marine and Environmental Sciences were recently awarded a three-year $369K NSF IRES grant titled “Systems-Based Transdisciplinary Approaches to Coral Reef Science and Conservation.” This grant will support three graduate-level courses focused on collaboration and interdisciplinarity, features necessary to address the existing and emergent needs of the coral reef scientific and conservation communities (the overarching topic of this program). The courses will involve research and education activities both in the United States and at remote field sites in Australia. ABOUT THE RECENT GRANT-FUNDED PROJECT Coral reefs are important ecosystems, with 30 percent of species in the ocean using the coral reef at some point in their lives, and nearby coastal communities receiving benefits such as protection from storm surge and access to resources. But when you take students to view a reef in Fort Lauderdale, they see reefs degraded by climate change, overfishing, disease, and other factors. On the other hand, Australia, the field location for this program, has more pristine coral reefs that allow students to see how these ecosystems could be better managed. Their funded graduate research program provides an opportunity to combine the research and teaching conducted by Nadler and Cyronak to allow students to directly experience unique coral reef environments, obtain hands-on research skills, and expand their scientific networks. This immersive experience will allow students to learn much more than they could in a university-based classroom or laboratory setting. Furthermore, research is an important skill for any career in science, including non-academic ones, so the program will support students interested in pursuing diverse career paths. Participating faculty in this program, from both the United States and Australia, come from diverse subspecialties and fields of coral reef science. This interdisciplinary approach is key for studying coral reefs, as these broad perspectives will help students tackle the large problems facing reefs globally. NATIONAL SCIENCE FOUNDATION GRADUATE RESEARCH PROGRAM RESEARCH SPOTLIGHTS

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 9 N FUNDS FOR INTERDISCIPLINARY M IN CORAL REEF SCIENCE

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 10 ROSE LEEGER Farquhar Honors College student Rose Leeger has developed an app that optimizes the data collection process for researchers in the field. The app, called “Everglades Research for Mosquitofish Data Collection,” allows researchers to upload pictures and input data into premade categories for a more e cient and accurate method of data collection. Leeger, a junior who is triple majoring in marine biology, environmental science, and biology created the app using software on ESRI’s ArcGIS system as part of her final project in her Geographic Information Systems course. The app has proven to be a handy alternative to the waterproof paper and pencils previously used in the field, allowing Leeger and her peers to conveniently collect and organize data on their phones. This data is then uploaded to an online data collection system that makes it easy for them to locate past data and identify trends in their research. Leeger plans to continue pursuing her passion for marine environment conservation by getting her Ph.D. to become a professor who can inspire future generations to do the same. NABIHA ATIQUZZAMAN A junior in the Dr. Kiran C. Patel College of Osteopathic Medicine (KPCOM), Nabiha Atiquzzaman is pursuing her Bachelor of Science in Public Health. Her research project with Jessica Brown, Ph.D., and Katie Crump, Ph.D., faculty from the Halmos College of Arts and Sciences, involves the exploration of methods in identifying volatile organic compounds (VOCs) indicative of periodontal disease. This breakthrough methodology of VOC use has shown to be a way to not only diagnose, but also prevent other diseases— not just limited to periodontal disease. By working in the lab with VOC collection analysis, conducting literature reviews /presentations, and running data analyses, Atiquzzaman has learned the global importance of this research and its applicability to all specialties of medicine. When she completes her undergraduate studies, Atiquzzaman aspires to continue her education by joining one of the graduate programs KPCOM has to o er. STUDENT SPOTLIGHTS

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 11 GRETCHEN SPENCER A second-year graduate student in NSU’s Master of Science in Marine Science program, in the Halmos College of Arts and Sciences, Gretchen Spencer works in the lab of Tyler Cyronak, Ph.D., which focuses on biogeochemical cycles in marine and coastal ecosystems—such as reefs, seagrass beds, and mangroves—and how these systems may be impacted by climate change. Spencer’s long-term career goal is to work in the policy sector to address major societal issues related to the environment. As a step toward this goal, after defending her thesis next year, she will be applying for a fellowship that will support working on environmental policy issues in the federal government. COLTON SIMMONS Fourth-year student in the College of Pharmacy, Colton Simmons is pursuing his Doctor of Philosophy (Ph.D.) in Pharmaceutical Sciences through the college’s Molecular Medicine and Pharmacogenomics concentration. He currently works in the AutoNation Institute for Breast Cancer Research and Care, run by Jean Latimer, Ph.D., located on the fourth floor of the Center for Collaborative Research. Simmons’ research involves the DNA repair pathway and nucleotide excision repair (NER) in breast cancer. He is part of a team that focuses on treatment mechanisms and approaches. Latimer’s lab discovered a microRNA that decreases NER repair in breast cancer cell lines, thus making them sensitive to chemotherapy. This has a tremendous implication for how to treat late-stage breast cancer and decrease the amount of chemotherapy required for treatment. When his doctorate is complete, Simmons aspires to work in industry, namely in a pharmaceutical company doing benchwork in their research and development unit.

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 12 NSU’s Core Research Facilities, located in the CCR, promote research excellence, o ering five di erent facilities available to all NSU research programs and their collaborating partners. Operating as fee-for-service facilities, all are available to external researchers as well. For a description of services, equipment, and pricing, or to request a quote, please visit nova.edu/research/core -facilities or email Robin Krueger, Ph.D., scientific director for research facilities at rkrueger1@nova.edu. FLOW CYTOMETRY NSU’s Flow Cytometry Core Facility provides researchers with sophisticated methods and instrumentation in flow cytometry, for the fluorescence analysis and preparative sorting of both human and mouse cells to the BSL-2 plus level. The principal assets of the core consist of an analytic instrument (one BD Fortessa X-20 SORP) and one sorting instrument (BD AriaFusion SORP). The core also provides data analysis support and operates workstations with FACSDiva and FlowJo software. IMAGING NSU’s Imaging Core Facility provides users with state-of- the-art imaging instrumentation and microscopy training. The principal assets of the core consist of the following: a confocal microscope (Zeiss LSM 880), an inverted automated imaging system (Life Technologies EVOS), and a highcontent screening platform (CellInsight CX7). NSU CORE FACILITIES GENOMICS AND BIOINFORMATICS NSU’s cutting-edge Genomics Core Facility (GCF) provides access to sophisticated technologies for the study of functional genomics with a focus on rapid run nextgeneration sequencing (NGS) on Illumina’s NextSeq 500 platform and direct multiplexed measurement of gene expression using NanoString’s novel digital color-coded barcode technology on the nCounter analysis system. The GCF specializes in library construction for various sequencing applications including whole genome sequencing, exome sequencing, and transcriptomic profiling. Support services using customized open-source and commercial software for data analysis are o ered in conjunction to enhance research project goals.

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 13 NSU RESEARCH INSTITUTES AND CENTERS To e ciently address key issues facing humanity, NSU has established several research institutes and centers using a multidisciplinary, interprofessional approach. These currently include • Broward County Sea Turtle Conservation Program and Marine Environmental Education Center • Center For Drug Discovery and Development (CD3) • Deep Pelagic Nekton Dynamics of the Gulf of Mexico (DEEPEND) Consortium • Emil Buehler Research Center for Science, Technology, Engineering, and Mathematics • Guy Harvey Research Institute • Institute for Natural and Ocean Sciences Research • Institute for Neuro-Immune Medicine • National Coral Reef Institute • NSU AutoNation Institute for Breast Cancer Research and Care • NSU Cell Therapy Institute • Rumbaugh-Goodwin Institute for Cancer Research • Save Our Seas Shark Research Center VIVARIUM NSU’s state-of-the-art Vivarium Core Facility is outfitted with Tecniplast Green Line IVC cages. Each room is equipped with temperature, humidity, and light controls. In addition, all holding rooms have VHP ports to maintain an SPF environment. The Vivarium contains two separate holding areas: a barrier suite and a non-barrier suite. NSU’s animal care and use program is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care. CELL THERAPY CORE NSU’s Cell Therapy Core Facility provides expertise in processing of cells from primary tissues, expansion and di erentiation of cells, including immune and stem cells, genetic modification of cells by viral vectors, and development of cell-based therapy products, among other services. The main goal is to support research by providing GLP-quality laboratory space, various well-established SOP-driven processes and technical/lab support by experienced sta assistants. We ensure a high quality research environment by providing a HEPA filter particle controlled GLP-quality cell and tissue processing laboratory.

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 14 NSU TECHNOLOGIES NSU is able to recognize high-potential technologies, assess their technical and commercial feasibility, secure patent protection, and conduct transactions with commercialization partners for the ultimate benefit of the public. NSU technologies that are ready for commercialization include • automated landing gear systems for trailers • a computational model to predict drug treatment courses • a portfolio of small-molecule cancer therapeutics • comprehensive genetic data for complex diseases • diagnostic for genetic mutations • digital authentication/auditing of pharmacy programs • digital career guidance system for minorities in a health care profession • electronic coordination of health care • image compression and encryption • modified natural killer cells for immunotherapy • novel method for diagnosing complex immune diseases • novel method for modulating oncolytic viruses • novel therapy for skin cancer • novel treatment for breast cancer • novel treatment for lung diseases • novel vaccine for HIV • system for reducing adverse health events in assisted living facilities • the delivery of personalized health care information • therapies for treatment of heart failure Please contact the O ce of Technology Transfer for more information, at nova.edu/ott.

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 15 105* The university receives funding from agencies and organizations. * This number represents external funders for sponsored programs and clinical trials. of total funding—or $68,006,118 —supports research. of total funding—or $84,483,976 —is funded directly by the federal government. of total funding goes to the Dr. Kiran C. Patel College of Osteopathic Medicine. 214 proposals were processed through the O ce of Sponsored Programs, with the largest number—67— submitted by the Halmos College of Arts and Sciences, followed by the College of Pharmacy and the Dr. Kiran C. Patel College of Osteopathic Medicine, with 26 proposals each. $139,879,600 is the total for the university’s sponsored funding for research, community service, and teaching/ training projects. 48.6% 60% 35% 25% of total funding goes to the Halmos College of Arts and Sciences. SPONSORED FUNDING BY THE NUMBERS—FY 2021 HIGHER EDUCATION R&D EXPENDITURES AT PRIVATE INSTITUTIONS Ranked by all Research and Development (R&D) Expenditures Source: National Science Foundation (NSF), Higher Education Research and Development Survey, FY 2020 Rank Institution 2020 65 Morehouse School of Medicine $29,813 66 Illinois Institute of Technology $29,122 67 Chapman University $26,660 68 Nova Southeastern University $26,035 69 Villanova University $25,505 70 Catholic University of America $25,221 71 Loma Linda University $25,077 72 Albany Medical College $23,510 NSF HERD Historical FY 2016–FY 2020 $0 $6,000,000 $12,000,000 $18,000,000 $24,000,000 $30,000,000 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 $24,566,567 $26,034,709 $19,558,627 $23,296,308 $22,508,896

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT 16 FEDERAL AGENCIES Centers for Disease Control and Prevention Health Resources and Services Administration National Science Foundation NIH—National Cancer Institute NIH—National Institute of Dental and Craniofacial Research NIH—National Institute of Environmental Health Sciences NIH—National Institute of General Medical Sciences NIH—National Institute on Aging NIH—National Institute on Minority Health and Health Disparities Substance Abuse and Mental Health Services Administration U.S. Department of Education U.S. DOC—National Oceanic and Atmospheric Administration U.S. DOD—National Security Agency U.S. DOD—Naval Surface Warfare Center U.S. DOD—O ce of Naval Research U.S. DOD—U.S. Army Contracting Command—Aberdeen Proving Ground U.S. DOD—U.S. Army Corps of Engineers U.S. DOD—U.S. Army Medical Research Acquisition Activity U.S. DOI—O ce of Insular A airs U.S. DOI—U.S. Geological Survey USDA—Rural Development, Rural Utilities Service VA Boston Healthcare System STATE AGENCIES Alaska Department of Fish and Game Department of Natural and Environmental Resources, Government of Puerto Rico Florida Department of Children and Families Florida Department of Environmental Protection Florida Department of Health Florida Department of State, Division of Cultural A airs Florida Fish and Wildlife Conservation Commission LOCAL GOVERNMENT Broward County Broward County Cultural Division Broward County Sheri ’s O ce Miami-Dade County The Children’s Trust Town of Lauderdale-By-The-Sea FUNDING ASSOCIATIONS (Foundations, For-Profit Corporations, Nonprofit Corporations, and Universities) American Association of Colleges of Osteopathic Medicine American Genetics Association Association of Psychology Postdoctoral and Internship Centers Bok Tower Gardens Broward Regional Health Planning Council, Inc. Case Western Reserve University Chicago Zoological Society Clean Caribbean Corporation (d/b/a Clean Caribbean and Americas) Community Foundation of Broward Community Health of South Florida, Inc. Coral Restoration Foundation Cornelia T. Bailey Foundation Dr. John T. MacDonald Foundation Early Learning Coalition of Broward County Florida Blue Foundation Florida Humanities Council Florida International University Florida State University Genome Research Limited Icahn School of Medicine at Mount Sinai International Association of Medical Science Educators J. Craig Venter Institute Jaeb Center for Health Research Miami-Dade College Middle Tennessee University Optometry Giving Sight Osteo Science Foundation Patient Centered Outcomes Research Institute Physician Assistant Education Association Qatar University Rochester Institute of Technology Saint Louis Zoo WildCare Institute Save Our Seas Foundation Sea Turtle Conservancy Seafood Industry Research Fund Texas A&M University The Frederick A. DeLuca Foundation The Ohio State University The Regents of the University of California (University of California—Los Angeles) The Roskamp Institute Trustees of Boston University United Way of Broward County University of California San Diego University of Colorado—Denver University of Florida University of Maine University of Maryland Center for Environmental Science University of Miami University of North Carolina—Chapel Hill Washington University in St. Louis Yale University FUNDING AGENCIES—FY 2021 The university received funding from 105 agencies and organizations, including clinical trials. Due to confidentiality obligations, not all of these funders are listed above.

RESEARCH METRICS—FY 2021

Coral Scans at Halmos College of Arts and Sciences

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 19 OVERVIEW AND HIGHLIGHTS UNIVERSITY-WIDE SPONSORED FUNDING—FY 2012–FY 2021 $0 $32 $64 $96 $128 $160 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 FY 2012 $63.9 $58.5 $65.6 $79.7 $122.7 $114.8 $82.2 $86.9 $95.8 $107.7 $119.4 $126.9 $139.9 ARRA $18.3 HEERF $25.1 $82.2 ARRA $2.5 Total Dollar Amount of Cumulative Active Awards in Millions $68.1 ARRA $2.5 HEERF $4.2 $61.1 ARRA $2.6 NSU’s total sponsored funding demonstrates an overall upward trend over the last decade, despite a restrained funding landscape and the close of several American Recovery and Reinvestment Act (ARRA) projects, including the $15 million National Institute of Standards and Technology (NIST) award to construct the Center of Excellence for Coral Reef Ecosystems Research. The administration and support of NSU’s research, core facilities, sponsored programs, clinical research, and technology transfer in FY 2021 continues to expand and improve as the university’s research performance and capacity grows. NSU’s total sponsored funding continued to demonstrate an upward trend as it has for over a decade. The research metrics that follow represent FY 2021 activity in external sponsored funding, internal grant programs, clinical research, and technology transfer. In summary, at the close of FY 2021, the university’s sponsored funding totaled $139.9 million, which represents a 10 percent increase since FY 2020 and a 70 percent increase since FY 2012. Funding to support research represents 49 percent of this total with teaching/training and service comprising the balance. The university is receiving sponsored funding from 100 di erent funding entities, with the largest amount, 60 percent, coming directly from the federal government. Additionally, state and local government represented 17 and 15 percent of total funding, respectively. Funding from other nonprofit corporations, foundations, and other universities round out the sponsored funding portfolio. Clinical research in FY 2021 was implemented by four NSU colleges, with the highest activity in the College of Dental Medicine. Technology Transfer activity in FY 2021 included 11 invention disclosures, 5 patent applications, and 6 issued patents.

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 20 $0 $20 $40 $60 $80 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 Research Community Service Training Total Dollar Amount of Cumulative Active Awards in Millions $55.9 $59.0 $74.7 $67.3 $68.0 $62.9 $44.1 $15.5 $8.9 $7.5 $10.1 $8.2 $32.4 $38.5 $36.5 SPONSORED FUNDING ALLOCATIONS FOR RESEARCH, COMMUNITY SERVICE, AND TRAINING INITIATIVES (Comparison of FY 2017–FY 2021) AWARDS BY DIRECT SPONSOR TYPE—FY 2021 n Federal Government 60% $84,483,976 n State Government 17% $24,059,471 n Local Government 15% $20,352,377 n Universities 5% $7,075,649 n For-Profit Corporations 1% $1,264,318 n Nonprofit Corporations 1% $1,237,152 n Foundations 1% $1,037,055 n Other <1% $369,602 Total $139,879,600 PROPOSALS SUBMITTED—FY 2012–FY 2021 0 50 100 150 200 250 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 FY 2012 178 176 204 217 216 214 214 184 166 132

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 21 PROPOSALS SUBMITTED BY UNIT—FY 2021 SPONSORED FUNDING BY UNIT—FY 2021 n Halmos College of Arts and Sciences 31% 67 n College of Pharmacy 12% 26 n Dr. Kiran C. Patel College of Osteopathic Medicine 12% 26 n H. Wayne Huizenga College of Business and Entrepreneurship 8% 18 n Dr. Kiran C. Patel College of Allopathic Medicine 8% 17 n College of Psychology 7% 14 n College of Dental Medicine 5% 11 n Abraham S. Fischler College of Education and School of Criminal Justice 3% 7 n College of Computing and Engineering 3% 6 n Dr. Pallavi Patel College of Health Care Sciences 3% 6 n NSU Art Museum Fort Lauderdale 2% 5 n O ce of the President 2% 4 n Rumbaugh-Goodwin Institute for Cancer Research 1% 2 n College of Optometry <1% 1 n Alvin Sherman Library, Research, and Information Technology Center <1% 1 n Ron and Kathy Assaf College of Nursing <1% 1 n Enrollment and Student Services <1% 1 n University School <1% 1 n Shepard Broad College of Law <1% 1 Total 214 n Dr. Kiran C. Patel College of Osteopathic Medicine 35% $49,026,496.85 n Halmos College of Arts and Sciences 25% $34,983,189.41 n O ce of the President 18% $25,070,131.00 n College of Dental Medicine 10% $13,551,656.55 n O ce of Academic A airs 4% $5,504,819.00 n College of Computing and Engineering 2% $2,264,094.00 n College of Psychology 2% $2,465,914.38 n Dr. Kiran C. Patel College of Allopathic Medicine 1% $2,011,838.00 n College of Pharmacy 1% $1,563,054.00 n Abraham S. Fischler College of Education and School of Criminal Justice 1% $1,111,247.93 n Facilities Management <1% $908,861.00 n Dr. Pallavi Patel College of Health Care Sciences <1% $853,694.00 n College of Optometry <1% $285,429.30 n NSU Art Museum Fort Lauderdale <1% $255,261.00 n University School <1% $13,800.00 n Alvin Sherman Library, Research, and Information Technology Center <1% $5,400.00 n H. Wayne Huizenga College of Business and Entrepreneurship <1% $4,713.00 Total $139,879,599.42

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 22 RESEARCH FUNDING BY UNIT—FY 2021 COMMUNITY SERVICE FUNDING BY UNIT—FY 2021 TEACHING/TRAINING FUNDING BY UNIT—FY 2021 n Halmos College of Arts and Sciences 46% $31,239,856 n Dr. Kiran C. Patel College of Osteopathic Medicine 37% $25,290,549 n College of Dental Medicine 10% $6,637,906 n Dr. Kiran C. Patel College of Allopathic Medicine 2% $1,607,350 n College of Psychology 2% $1,527,642 n College of Pharmacy 2% $1,154,609 n Abraham S. Fischler College of Education and School of Criminal Justice 1% $499,098 n College of Optometry 1% $44,395 n H. Wayne Huizenga College of Business and Entrepreneurship <1% $4,713 Total $68,006,118 n College of Dental Medicine 37% $3,296,476 n Halmos College of Arts and Sciences 29% $2,625,872 n Facilities Management 10% $908,861 n College of Psychology 10% $892,940 n Dr. Pallavi Patel College of Health Care Sciences 7% $600,872 n Dr. Kiran C. Patel College of Osteopathic Medicine 4% $320,219 n NSU Art Museum Fort Lauderdale 3% $255,261 n Abraham S. Fischler College of Education and School of Criminal Justice <1% $25,000 n College of Optometry <1% $15,026 Total $8,940,527 n O ce of the President 40% $25,070,131 n Dr. Kiran C. Patel College of Osteopathic Medicine 37% $23,415,730 n O ce of Academic A airs 9% $5,504,819 n College of Dental Medicine 6% $3,617,274 n College of Computing and Engineering 3% $2,264,094 n Halmos College of Arts and Sciences 2% $1,117,462 n Abraham S. Fischler College of Education and School of Criminal Justice 1% $587,150 n College of Pharmacy 1% $408,445 n Dr. Kiran C. Patel College of Allopathic Medicine <1% $404,488 n Dr. Pallavi Patel College of Health Care Sciences <1% $252,822 n College of Optometry <1% $226,008 n College of Psychology <1% $45,332 n University School <1% $13,800 n Alvin Sherman Library, Research, and Information Technology Center <1% $5,400 Total $62,932,955

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 23 Summary of PFRDG Annual Outcomes (Through the FY 2018 Cycle) Fiscal Year Presentations Publications External Grant Proposals Submitted/Funded External Grants Total 2001 26 8 4/2 $98,000 2002 29 11 8/3 $622,481 2003 43 28 7/6 $247,472 2004 18 14 6/3 $197,582 2005 43 20 4/2 $50,000 2006 22 7 1/0 $0 2007 20 6 4/3 $356,449 2008 34 31 11/2 $206,899 2009 25 23 11/4 $316,949 2010 46 32 12/5 $509,837 2011 39 43 25/9 $316,398 2012 64 29 7/1 $10,000 2013 54 26 20/9 $789,471 2014 121 28 38/9 $4,399,740 2015 72 9 18/5 $1,959,697 2016 37 14 12/1 $75,000 2017 32 11 17/3 $435,722 2018 7 6 6/0 $0 TOTAL* 732 346 211/67 10,591,697 PRESIDENT’S FACULTY RESEARCH AND DEVELOPMENT GRANT PROGRAM The President’s Faculty Research and Development Grant (PFRDG) program, established in 1999, has been successful in meeting its goals of fostering inquiry, research, and creative professional activity at NSU. Since the beginning of the PFRDG program, the NSU Board of Trustees has allocated more than $2 million to support and sustain this university initiative. For each award given, 50 percent of the funding comes from interest generated from the allocation, while the other 50 percent comes from the winning faculty members’ colleges. PFRDG funding complements existing resources for faculty support in the academic units by providing seed money for a new research area, for which external funding will be sought, or by expanding current research to a new level of competitiveness for external funding. In 2018, a new PFRDG track was added to support a small number of scholarly research projects contributing to general knowledge of the discipline, but for which external funding is not an expected outcome. Each spring, NSU faculty members across the university compete for these grants that award up to $15,000. In the 22-year history of these awards, faculty members and students have shared $5,636,596 in financial support. This investment has produced $10,591,697 in external awards. Grant winners have come from each of the university’s academic units. The table below reflects the number of presentations, publications, and external funding proposals submitted and funded as a direct result of this program. *Since the beginning of the PFRDG program, NSU has had four patents submitted and one issued as a result of funding from this program.

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 24 0 50,000 100,000 150,000 200,000 250,000 300,000 350,000 400,000 FY 2022 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 $370,828 $376,536 $368,908 $295,960 $296,697 $352,663 $355,838 $368,048 $349,408 $350,030 0 10 20 30 40 50 60 70 80 FY 2022 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 52 25 52 30 32 29 29 56 63 37 36 62 37 65 39 40 48 24 24 23 0 10 20 30 40 50 60 70 80 90 FY 2022 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 55 66 68 67 83 53 61 54 54 56 54 56 54 47 47 46 43 43 43 41 Total Submissions Faculty Members Total Awards Students PFRDG TOTAL AMOUNT FUNDED—FY 2013–FY 2022 PFRDG TOTAL SUBMISSIONS AND AWARDS—FY 2013–FY 2022 TOTAL FACULTY AND STUDENTS SUBMITTING TO PFRDG—FY 2013–FY 2022

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 25 Since its inception in 2002, the NSU Quality of Life (QOL) program’s purpose has been to support faculty and student research that is aimed at promoting positive and lasting change within the Broward County community. Funding is prioritized for research that addresses such issues as infant mortality, obesity, elderly services, child abuse, juvenile justice, autism, foster care, and mental health. For its FY 2022 competition, held in the spring of 2021, QOL programs made 4 new awards totaling $60,000, which involved 28 faculty members and 6 students and represented 10 academic units and 10 community agencies. These awards brought QOL’s 19-year funding total to $749,348 in support of 68 projects. QOL TOTAL AMOUNT FUNDED— FY 2013–FY 2022 0 22,000 44,000 66,000 88,000 110,000 FY 2022 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 $59,363 $60,000 $72,162 $39,706 $29,846 $29,972 $101,051 $19,575 $27,760 $49,924 0 3 6 9 12 15 FY 2022 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 7 7 7 12 4 4 4 4 6 3 5 5 3 3 3 2 2 8 5 5 0 5 10 15 20 25 30 35 FY 2022 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 6 6 9 9 12 4 12 13 15 4 8 4 10 4 6 4 31 28 21 7 Total Submissions Faculty Members Total Awards Students QOL TOTAL SUBMISSIONS AND AWARDS—FY 2013–FY 2022 TOTAL FACULTY AND STUDENTS SUBMITTING TO QOL—FY 2013–FY 2022 QUALITY OF LIFE PROGRAM

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 26 NSU CLINICAL RESEARCH Total Clinical Funding: $5,438,731.58 CLINICAL TRIAL FUNDING BY UNIT—FY 2021 TOTAL CLINICAL TRIAL FUNDING BY UNIT—FY 2009–FY 2021 $0 $700,000 $1,400,000 $2,100,000 $2,800,000 $3,500,000 Translational Research and Economic Development Dr. Pallavi Patel College of Health Care Sciences College of Pharmacy College of Optometry Dr. Kiran C. Patel College of Osteopathic Medicine College of Dental Medicine $3,007,878.00 $1,682,075.50 $560,203.08 $120,975.00 $55,100.00 $12,500.00 n College of Dental Medicine 76% $959,818.00 n College of Optometry 1% $14,720.00 n College of Pharmacy 6% $70,975.00 n Dr. Kiran C. Patel College of Osteopathic Medicine 17% $214,249.00 Total $1,259,762.00 LEADING THERAPEUTIC AREAS IN CLINICAL RESEARCH Dentifrices and Implants College of Dental Medicine Contact Lens Assessment in Youth, Dry Eye, and Retina Imaging College of Optometry Nutraceutical Intervention for Oxidative Stress College of Pharmacy Nutraceutical Intervention NSU’s Pediatric Dental Clinic

NSU TRANSLATIONAL RESEARCH AND ECONOMIC DEVELOPMENT—RESEARCH METRICS 27 NSU INVENTION DISCLOSURES AND PATENT APPLICATIONS—FY 2012–FY 2021 0 20 40 60 80 100 120 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 FY 2012 11 35 21 45 6 25 24 50 51 9 19 29 55 56 11 32 30 58 61 66 13 40 77 15 46 85 96 106 117 11 0 2 4 6 8 10 12 FY 2021 FY 2020 FY 2019 FY 2018 FY 2017 FY 2016 FY 2015 FY 2014 FY 2013 FY 2012 0 3 4 8 2 4 5 5 5 3 4 4 5 5 2 3 6 3 5 8 2 5 11 2 6 8 11 10 11 0 CUMULATIVE NSU INVENTION DISCLOSURES AND PATENT APPLICATIONS—FY 2012–FY 2021 Invention Disclosures Cumulative Invention Disclosures Patent Applications Cumulative Patent Applications Patents Issued Cumulative Patents Issued NSU TECHNOLOGY TRANSFER AND COMMERCIALIZATION

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