Barry and Judy Silverman College of Pharmacy—Ph.D. Program 223 score matching approaches. The course will be presented in an application context. Examples from social, behavioral, economic, and administrative studies will be used to illustrate key ideas and methods. (48-0-3) PHRE 7207—Secondary Data Analysis of Pharmacy-Related Sources This course gives students the opportunity to apply the skills learned in the research design and biostatistics courses by completing a secondary data analysis research project using a federal database. Students will write a basic research protocol and become familiar with the basic structure and methodology of the United States National Health and Nutrition Examination Survey (NHANES) database. Students will prepare a dataset, conduct descriptive and basic statistical analyses using SPSS, write an abstract, and deliver a presentation to a small audience. (48-0-3) PHRE 7208—Advanced Pharmacokinetics This course will explain the model development techniques that can be utilized for complex pharmacodynamic systems. Advanced data analysis techniques and modem pharmacokinetic theory will be discussed. (48-0-3) PHRE 7210—Modern Medicine This course aims to integrate various multidisciplinary domains of science and technology to address the development and translation of advanced multifunctional pharmaceuticals for targeted therapy of specific organs/tissues/cells in hard-totreat diseases. The course describes different types of smart, multifunctional drug delivery systems (DDSs) and drug delivery devices (DDDs) using various advanced nanobiomaterials. The course elaborates on the applications of nanoscale multimodal DDSs/DDDs in targeted therapy of detrimental diseases, such as solid tumors. It outlines cell-/tissue-specific targeted therapy and provides overviews on the applications of theranostics for simultaneous diagnosis and therapy. (48-0-3) PHRE 7213—Epidemiology of Drug Use, Abuse, and Misuse This course is designed to introduce doctoral students to the epidemiology of drug use, misuse, and abuse. The course focuses on drug use, misuse, and abuse as social phenomena and deals with the history of drug use and regulatory attempts in America; pharmacology and use patterns related to specific drugs; use, abuse, and misuse as medical, psychological, and social concepts; drug importation, manufacture, and distribution (including both the legal and illegal drug industries); perspectives on the etiology of drug use/abuse; drug abuse prevention and educational programs; and approaches to drug abuse treatment. (48-0-3) PHRE 7216—Pharmaceutical Polymers This course presents basic concepts and properties of polymers as related to formulation, development, and design of pharmaceutical dosage forms and products. It describes how basic principles of polymers—structural, physical, chemical, and mechanical properties—can be utilized in modifying and developing current and novel pharmaceutical products. Moreover, the course highlights important areas of polymer applications in controlled drug delivery, targeted drug delivery, tissue engineering, nanotechnology, and medical devices. (48-0-3) PHRE 7223—Drugs of Abuse This course covers types of substances abused, methods and routes of administration, the pertinent toxicokinetics, the pharmacological/toxicological mechanisms, and the clinical manifestations of drug abuse. The anatomical and neurochemical substrates of drugs of abuse are also described. Treatment of intoxication and withdrawal, societal impact of drug abuse, legal implications, and current trends of substance abuse are addressed as well. (48-0-3) PHRE 7252—Fundamentals of Pharmacognosy This course exposes graduate students to the field of pharmacognosy, with an emphasis on medicinal products derived from plants and other natural sources. The major classes of medicinally active natural products, their origin (nomenclature + taxonomy), structure, biosynthesis, and mode of action will be covered. The naturally derived constituents and their therapeutic efficacy will be discussed. Students will be required to develop a monograph for a bioactive plant or marine species, including a comprehensive summary of the peer-reviewed research available regarding its pharmacological profile. (48-0-3) PHRE 7350—Contemporary Issues in Pharmacy This course is designed to explore a broad spectrum of contemporary issues related to pharmacy practice, pharmaceutical industry, third-party payment, and health policy. It aims to increase student awareness and understanding of the change in pharmacy practices and their impacts to the U.S. healthcare system. (48-0-3) PHRE 7431—Oncologic Treatments and Pharmacogenomics This course introduces the basic molecular concepts of cancer and pharmacogenomics in the context of cancer treatment. It presents the current methodologies used in cutting-edge oncology for the treatment of two of the most common types of cancer: breast and colon. The standard-of-care combinatorial regimens will be presented, as well as the treatment scenarios that are applied to advanced-stage and recurrent disease. Drugs that have increased patient tolerance to these genotoxic regimens will also be discussed. Finally, the application of nextgeneration sequencing of tumor DNA or RNA to determine which of the more than 300 druggable mutations exist in these tumors will be discussed, primarily in the cancer-recurrence setting. Prognostic tests based on RNA expression from tumors will be covered. Discussion of the rationale for insurance coverage of pharmacogenomic variability will be covered as well. The impact of oncologic pharmacogenomics on future clinical trials will also be examined. (48-0-3)
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