Barry and Judy Silverman College of Pharmacy—M.S. in Pharmaceutical Sciences 211 PHRE 5222—Applied Pharmacology Students will use pharmacological principles to study the effects of therapeutic agents on the central nervous system, the endocrine system, the gastrointestinal system, blood, and blood-forming organs. It will address the rationale for the use of therapeutic agents; their effects on cells, tissues, organ systems, and patients; the mechanisms underlying these effects; the therapeutic value of specific drug effects; the limitation of the use of the agents; and the adverse effects of drugs. (48-0-3) PHRE 5224—Drugs of Abuse This course covers types of substances abused, methods and routes of administration, the pertinent toxicokinetics, the pharmacological/toxicological mechanisms, and the clinical manifestations of drug abuse. The anatomical and neurochemical substrates of drugs of abuse are also described. Treatment of intoxication and withdrawal, societal impact of drug abuse, legal implications, and current trends of substance abuse are addressed as well. (48-0-3) PHRE 5244—Fundamentals of Pharmacognosy This course provides an overview of medicinal drugs derived from plants and other natural sources. The major classes of medicinally active natural products, their origin (nomenclature+taxonomy), structure, biosynthesis, and mode of action will be covered. The naturally derived constituents and their therapeutic efficacy will be discussed. (48-0-3) PHRE 5351—Contemporary Issues in Pharmacy This course is designed to explore a broad spectrum of contemporary issues related to pharmacy practice, the pharmaceutical industry, third-party payment, and health policy. It will also increase student awareness and understanding of changes in pharmacy practices and its impact on the U.S. healthcare system. (48-0-3) PHRE 5432—Oncologic Treatments and Pharmacogenomics This course introduces the basic molecular concepts of cancer and pharmacogenomics in the context of cancer treatment. It presents the current methodologies used in cutting-edge oncology for the treatment of two of the most common types of cancer: breast and colon. The standard-of-care combinatorial regimens will be presented, as well as the treatment scenarios that are applied to advanced-stage and recurrent disease. Drugs that have increased patient tolerance to these genotoxic regimens will also be discussed. Finally, the application of nextgeneration sequencing of tumor DNA or RNA to determine which of the more than 300 druggable mutations exist in these tumors will be discussed, primarily in the cancer recurrence setting. Prognostic tests based on RNA expression from tumors will be covered. Discussion of the rationale for insurance coverage of pharmacogenomics will also be covered. The impact of oncologic pharmacogenomics on future clinical trials will be examined. (48-0-3) PHRE 5516—Health Disparities in Chronic Diseases: The Role of the Pharmacist This course presents the main causes and pathways to health disparities in the United States. It focuses on chronic diseases, such as diabetes, cancer, and cardiovascular diseases. Emphasis is given to disparities associated with access to medication and pharmacy services and to adherence. Students learn about pharmacy-led interventions aimed at reducing health disparities. They are expected to use epidemiological data to study the disparities and to formulate recommendations to the pharmacy field. Students are assessed through hands-on structured assignments. (48-0-3) PHRE 5999—Research in the Pharmaceutical Sciences In this course, students work under the direction/supervision of one or more faculty members in a research laboratory. Students are involved in planning and executing an approved research project using basic techniques of scientific research. Students will be awarded 3 or 4 semester credits on the basis of 48 laboratory hours per credit. (0-[144–192]-[3–4])
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