HPD Research Day | February 16, 2018

29 POSTER PRESENTATIONS Atrium Atrium – Poster 1 12:15-1:15 p.m. Opioid Complexation and Abuse Performance of Crosslinked Cellulose and Starch Derivatives Rand H. Ahmad, Ph.D. in Pharmacy Student, College of Pharmacy, Nova Southeastern University Christina M. Crum, BS, P4, College of Pharmacy, Nova Southeastern University Hamid Omidian, Ph.D., Professor, College of Pharmacy, Nova Southeastern University Objective. The objective was to determine the percentage of Dextromethorphan HBr (DEX) that, in the form of complex, could be loaded into two crosslinked anionic polymers, carboxymethyl starch (CMS) and carboxymethyl cellulose (CMC) at low and high ratios, and to determine the extent to which the complexation ratio influences the abuse deterrence capacity. Background. We previously disclosed polymer-drug complexes that can effectively minimize the amounts of extracted drug under abuse conditions. We have also shown that CMS and CMC have great potential to form effective polymer-drug complexes. Methods. CMS/CMC were mixed with DEX in water at 8:1 and 1.3:1 weight ratios. Followed by washing, the complexes were dried and milled. Drug loading was determined in 0.1N HCl. Accordingly, given amounts of the complexes (equivalent to 25 mg DEX) were dispersed in 10mL aqueous solutions. The % drug in solution was determined by UV Spectrophotometer. IR spectroscopy was used to characterize drug loading capacity. Results. At low and high drug/polymer ratios, the amounts of drug loaded onto 1g of polymers were respectively found 99mg and 117mg (for CMS) and 112mg and 602mg (for CMC). IR spectra coefficients were 0.98 and 0.85 for CMS and CMC complexes, respectively. Deterrence performance within the CMS group were comparable (≤ 6% differences), but CMC complexes showed up to 35% difference in their deterrence performance. Conclusion. Higher functionality of CMC offered higher loading capacity. The high- loaded complexes were found more sensitive to ions present in the solution. Grants. This study was supported by NSU Grant 335081 Atrium – Poster 2 12:15-1:15 p.m. Probe Penetration Method to Characterize Low Solid High Viscous Pharmaceutical Gel Compositions Rand H. Ahmad, Ph.D. in Pharmacy Student, College of Pharmacy, Nova Southeastern University Samaneh Alaei, College of Pharmacy, Nova Southeastern University Hamid Omidian, Ph.D., Professor, College of Pharmacy, Nova Southeastern University Objective. The objective was to develop a discriminatory analytical technique to evaluate rheological properties of low solid high viscous gel compositions used in the preparation of semi-solid pharmaceutical dosage forms. Background. Rheological properties of materials are frequently described in terms of viscosity, which is defined as resistance to flow. Compositions displaying strong gel consistency do not flow unless the applied stress exceeds certain value “Yield Stress”. In this study, we propose a Probe Penetration Method for better characterization of gels displaying yield stress when used at very low concentrations. Methods. Different types of carbomer solutions (carbomer homopolymer, copolymer, interpolymer, and polycarbophil) were prepared in water at different concentrations (0.1-1.0% w/w). Using sodium hydroxide, the pH of solutions was adjusted to 5.0-6.0, and the gel strength was measured using CT3-Texture Analyzer for non-neutralized and neutralized samples. The test records sample resistance to a penetrating stainless-steel probe (@ speed of 0.5mm/s). The test starts when the designated trigger load (10mN) is reached (at sample surface), then travelling 25mm distance representing sample center. Results. The control solutions, regardless of their concentrations, showed minimal differences in their gel strength values, 12-31mN. The results after neutralization demonstrated higher values and varied among different concentrations; carbomer homopolymer 18-196mN, copolymer 28-132mN, interpolymer 21-238mN, & polycarbophil 20-118mN. Conclusion. Given its discriminatory capability, the gel strength measurement by probe penetration method can be used in studying the rheological properties of highly viscous gel materials used at less than 1% concentrations. Grants. This study was supported by NSU Grant 335081