HPD Research Day | February 16, 2018

38 biotin, pantothenic acid and lipoate. Experimental characterization of the identified mutations utilizing human- derived intestinal HuTu-80 and brain U87 cell lines, showed impaired functionality ( 3 H-biotin uptake) of the two identified hSMVT mutants. In addition, our results (using live-cell confocal imaging) showed poor expression and cytoplasmic localization of the R94X mutant, while the R123L mutant was predominantly retained in the endoplasmic reticulum. Conclusion. This is the first reporting of mutations in the human SLC5A6 gene leading to defects in hSMVT, associated with a host of clinical abnormalities. Atrium – Poster 20 12:15-1:15 p.m. Pharmacists' Role in Minimizing the Problem of Polypharmacy Kevin Corneille, MS, P2, College of Pharmacy, Nova Southeastern University Objective. The purpose of this study was to take a panoramic view of potential ways HCP especially Pharmacists, can combat a problem that will not be going away for the foreseeable future. The approach taken to determine an appropriate course of action involved developing a poster focused on defining Polypharmacy and possible intervention strategies of health care providers. Background. The duality of medication is one of the most fascinating juxtaposition that faces healthcare providers. Medication is necessary to treat various ailments. However, the current chasm within healthcare when it relates to medication regimen and allocation is a serious public health issue. Polypharmacy involves the prescribing and consumption of many medications to treat a single ailment. In addition, such practices can lead to various adverse effects for the patient. Recent reports has shown increasing fear of over prescribing leading to underdosing. The importance of understanding Polypharmacy stems from patients who are currently at risk because of a lack of communication regarding their drug regimen. The concept of Polypharmacy is difficult to discuss because of the many moving parts involving Pharmacists and any other health care provider that interact with a patient’s medication. Methods. A broad search was conducted using various databases such as NCBI and PubMed Results. The reduction of Polypharmacy through Pharmacist intervention would lead to better patient outcomes. Conclusions: The literature suggests there are successful pathways in which Pharmacists can intervene in Polypharmacy. Solving Polypharmacy would signal less patient adverse reactions and better patient outcomes regarding their long-term health. Atrium – Poster 21 12:15-1:15 p.m. Therapeutic Polymers to Deter Intravenous Drug Abuse Christina M. Crum, BS, P4, College of Pharmacy, Nova Southeastern University Rand H. Ahmad, College of Pharmacy, Nova Southeastern University Hamid Omidian, Ph.D., Professor, College of Pharmacy, Nova Southeastern University Objective. This study was conducted to determine the percentage of Dextromethorphan HBr (DEX) that could be extracted in solutions from drug-loaded therapeutic polymers (AcDiSol and Explotab) and compare to physical blends of the same. Background. Currently marketed intravenous abuse-deterrent formulations are either crush- resistant or extraction-resistant (by forming viscous gels in solutions), each of which abusers could manipulate. In this work, we developed a new extraction-resistant approach, using drug-loaded therapeutic polymers. The drug loads are expected to remain complexed to the polymers when drug formulations are manipulated in various solvents. Methods. DEX-AcDiSol/Explotab (1:8) complexes were prepared in water. The complexes were dried and milled, and amounts equivalent to 25 mg DEX were dispersed in 10 mL aqueous solutions. The % drug in solution was determined via UV spectrophotometer. The deterrence efficiency was compared to physical mixtures of the same. Results. Drug extraction from both therapeutic polymers was < 10% in polar solvents and 40% v/v ethanol. Solvents with ions could extract > 50% of the drug, the AcDiSol therapeutic polymer being more susceptible with ~ 80% drug extraction in normal saline. Compared to their physical blends, AcDiSol and Explotab therapeutic polymers were ~ 10% and ~ 25% more effective in reducing drug extraction in polar solvents, respectively, and ~ 35% more effective in ethanol. Conclusion. While therapeutic polymers of DEX-loaded AcDiSol and Explotab significantly reduced drug extraction in polar and alcoholic solutions, further work is needed to overcome their vulnerability to ions. Grants. This study was funded by NSU grant 335081.