HPD Research Day | February 16, 2018

36 Objective. The purpose of this study was to assess the acute effects of consuming a pre-workout supplement on indices of muscular strength, endurance and mood states. Background. Earlier research has shown that various pre- workout supplements may aid exercise performance; however, when the placebo is matched for caffeine content with a supplement, it is not known if an ergogenic effect may occur. Methods. Fourteen exercise-trained subjects (7 female, 7 male) participated in this investigation. Subjects came to the lab twice with at least 7 days between testing sessions. The consumption of product or placebo was randomized. They arrived at the lab 3 hours fasted with no prior exercise that day. Subsequently, they consumed the supplement or placebo (mixed with 8-12 ounces of water) 30 minutes prior to testing. Participants’ mood was also assessed via a profile mood states questionnaire (POMS) 30 minutes after product or placebo was consumed. After taking the POMS questionnaire, subjects had their exercise performance assessed via the 1-RM bench press followed by bench press repetitions to failure at 60% of 1-RM with 30 seconds rest between sets (3 total sets). Results. There were significant differences (p < 0.05) between the supplement and placebo for the number of repetitions to failure as well as total weight lifted. However, there were no differences for any of the other parameters measured. Conclusion. The results demonstrated that the acute consumption of a pre-workout supplement can enhance muscular endurance; however, it has no effect on strength or mood states. Atrium – Poster 16 12:15-1:15 p.m. In-Vitro Drug Release from Abuse-Deterrent Therapeutic Polymers Breana N. Caturano, BA, P1, College of Pharmacy, Nova Southeastern University Rand Ahman, College of Pharmacy, Nova Southeastern University Christina Crum, BS, P4, College of Pharmacy, Nova Southeastern University Hamid Omidian, Ph.D., Professor, College of Pharmacy, Nova Southeastern University Objective. The objective was to evaluate the release of Dextromethorphan HBr (DEX) from its starch-based and cellulose-based therapeutic polymers in simulated gastric and intestinal media. Background. We have previously prepared DEX-loaded therapeutic polymers of crosslinked carboxymethyl derivative of cellulose (CMC) and starch (CMS), and evaluated their intravenous abuse-deterrence in different extracting solvents. Further studies were needed to confirm that such therapeutic polymers could maintain their therapeutic effectiveness under legitimate use. Methods. DEX-CMS/CMC complexes were mixed with binder and compressed into tablets. Using USP Apparatus II @ 50 rpm, dissolution studies were performed in two stages: Stage I (900mL 0.1N HCl), followed by Stage II (900mL water or pH 7.5 phosphate buffer). Samples of 5mL were withdrawn at predetermined time points with immediate media replacement. UV spectrophotometer was used to determine % drug release in two stages. Results. Immediate and complete drug release was achieved for all complexes in 0.1 N HCl (>95% after 15 minutes). Stage 2 in water and phosphate buffer showed >90% drug release after 24 hours, complying with the USP limit. Conclusion. Drug-loaded therapeutic polymers were found to be a successful approach in deterring intravenous drug abuse, while at the same delivering the intended drug amounts under therapeutic use. Full protonation of the polymer in gastric medium and lack of (or very slow) drug rebinding with the protonated polymer in simulated intestinal fluid makes this approach feasible in formulating both immediate and sustained release abuse deterrent opioid formulations. Grants. This study was supported by NSU Grant 335081. Atrium – Poster 17 12:15-1:15 p.m. Structural Factors Affecting Abuse Performance of Common Pharmaceutical Superdisintegrants Breana N. Caturano, BA, P1, College of Pharmacy, Nova Southeastern University Rand H. Ahmad, College of Pharmacy, Nova Southeastern University Hamid Omidian, Ph.D., Professor, College of Pharmacy, Nova Southeastern University Christina Crum, BS, P4, College of Pharmacy, Nova Southeastern University Objective. The objective was to evaluate the abuse deterrence performance of commercial superdisintegrants, carboxymethyl cellulose (AcDiSol) and carboxymethyl starch (Explotab), to entrap cationic drug model (Dextromethorphan HBr, DEX) in solvents commonly used in IV drug abuse. Background. AcDiSol and Explotab (Regular, Low pH, and CLV) are crosslinked substituted cellulose and starch, respectively. We previously found out that both polymers deter drug abuse due to their binding and swelling features. Although both polymers are supplied