HPD Research Day | February 16, 2018

57 for all variables via. SPSS 20. Results. A descriptive analysis of the session demonstrated a mean PL of 425.51 ± 74.11, PLM of 5.45 ± 1.0, MHR of 207.33 ± 15.32, HR of 138.80 ± 5.41. Conclusion. The exploratory data and use of validated microsensors may contribute to the quantifying of variables such as PL and PLM during a MMA sparring session. Grants. N/A Atrium – Poster 56 12:15-1:15 p.m. The Significance of the Renin Angiotensin System in the Screening, Diagnosis, and Treatment of Colorectal Cancer (CRC) Gabriela Perez, DO, Palmetto General Hospital Christopher Neagra, DO, Palmetto General Hospital Rafael Valenzuela-Tapia, DO, Palmetto General Hospital Julia Ladna, OMS-III, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University Andres Rodriguez, OMS-III, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University Benjamin Goldstein, University of Florida Robert Speth, PhD, Professor, College of Pharmacy, Nova Southeastern University Objective. The purpose of this study is to evaluate the possible use of angiotensin receptor biomarkers and angiotensin receptor blocker medications (ARBs) in the diagnosis and treatment of certain colorectal cancers (CRC). Background. Colorectal cancer (CRC) remains the third most common cause of cancer death in the United States. Multiple studies have demonstrated the overexpression of the A-II type 1 receptor (ATR1), which has been overexpressed in several human cancers. Methods. Methods as described in Goldstein et al.4. Results. In this analysis, we observed statistically significant alterations in many RAS related components gene expression in colorectal cancer specimens. AT1 receptor gene expression was unchanged. There was a highly significant reduction in Mas1 gene expression. There was a substantial increase in neprilysin gene expression in colorectal tumor tissue. Of note, Neprilysin is inhibited by sacubitril a component of the heart failure drug, Entresto® (sacubitril/ valsartan). It will be of interest to determine if patients on Entresto® have a reduction in colorectal cancer incidence. Conclusion. This analysis is consistent with involvement of the RAS in colorectal cancer. However, the pathological significance of the changes in RAS related gene expression will require continued assessment of the effects of drugs that inhibit or enhance the activities of these various RAS related components on the incidence and the survivability of colorectal cancer. Atrium – Poster 57 12:15-1:15 p.m. The Effect of Osteopathic Manipulative Therapy on a Patient Presenting with Thoracic Outlet Syndrome and Concomitant Cervical Scoliosis Rajinder Persaud, BS, OMS-III, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University Introduction. This case study was performed to ascertain the effects of OMT on a patient with TOS and Cervical Scoliosis. Existing literature shows that TOS secondary to compression of the brachial plexus or the subclavian artery/vein can be managed with intense myofascial release, stretching and OMT with the most efficacious intervention currently being decompressive surgery. To date, no evidence has been complied relating the effects of OMT on a patient with TOS along with Cervical Scoliosis. Case Presentation. One female patient (Caucasian, Age 39) with complaints of Cervicalgia secondary to cervical scoliosis and right upper extremity numbness, weakness and tingling secondary to TOS was evaluated for increases in strength and ROM and decreases in pain scale of the cervical spine and right upper extremity due to the effects of OMT along with a moist heat modality. Deviation from the Expected. This case is unique in the fact that this patient presents with TOS along with a concomitant scoliosis of the cervical spine. Also, all techniques were performed using a moist heat modality. Discussion. Since this patient is healthy and active more direct techniques were employed. Modalities utilized were Muscle Energy, Direct Myofascial Release and Soft Tissue. Areas of focus were the scalenes, trapezius, pec minor and the clavicle (AC and SC joints). Conclusion. The findings of this case report could help create a treatment plan utilizing OMT and a moist heat modality for a Sports Medicine or Neuromuscular Medicine patient that presents similarly.