HPD Research Day | February 16, 2018

47 Atrium – Poster 37 12:15-1:15 p.m. Determining Syringeability by Measuring Aspiration Volume of Polymer Solutions at Different Temperatures Yogesh N. Joshi, Ph.D., Ph.D. in Pharmacy Student, College of Pharmacy, Nova Southeastern University Riann Forbes, P1, College of Pharmacy, Nova Southeastern University Hamid Omidian, Ph.D., Professor, College of Pharmacy, Nova Southeastern University Objective. The study was conducted to determine syringeability of methyl cellulose (MC), carboxymethyl cellulose (CMC), and poly(ethylene oxide) (PEO) in terms of aspiration volume when subjected to different temperatures for abuse. Background. Despite the fact that synthetic gelling agents such as PEO are frequently used in deterring drug abuse via injection, solution properties of such polymers are sensitive to high temperatures of extraction, and as such less temperature sensitive gelling agents are highly demanded. Methods. A CT3 Texture Analyzer with a syringe probe was used to draw PEO, MC and CMC solutions (0.5, 1, 2, 2.5, and 5% w/v) into the syringe. The syringe plunger was attached to the probe, and the needle was immersed into the solution. The probe was pulled up to 40 mm mark at the speed of 0.5 mm/sec. A similar study was conducted at an elevated temperature. The polymer solutions were poured into a jacketed glass beaker attached to a water bath maintained at 90 o C. The aspiration volumes were measured after 5 min. Results. At room temperature, aspiration volumes suggested greater difficulty level of the CMC solutions for syringeability compared to MC and PEO solutions. However, at elevated temperatures, aspiration of MC solutions did not lead any volume. The PEO solutions had lowest resistance for aspiration in both conditions. Conclusion. Aqueous solutions of cellulose derivatives, CMC and MC show better resistance toward syringeability than PEO solutions at room temperature as well as at elevated temperatures. Atrium – Poster 38 12:15-1:15 p.m. Effect of Shear Stress History on Polymer Solution Aspiration Yogesh N. Joshi, Ph.D., Ph.D. in Pharmacy Student, College of Pharmacy, Nova Southeastern University Riann Forbes, P1, College of Pharmacy, Nova Southeastern University Hamid Omidian, Ph.D., Professor, College of Pharmacy, Nova Southeastern University Objective. The study was conducted to determine behavior of methyl cellulose (MC), and carboxymethyl cellulose (CMC) in comparison with poly(ethylene oxide) (PEO) when subjected to shear stress for prolonged duration. Background. Use of gel forming agents in abuse deterrent formulations can potentially prevent drug abuse via IV route. However, these agents are susceptible to high shear conditions of multiple aspirations, which for the first time will be studied in this research. Methods. About 3 mL of 1% w/v solutions of PEO, CMC, and MC were taken into glass vials. A Brookfield CT3 texture analyzer with syringe probe was used to measure the drawing force. The syringe plunger was attached to the probe while the attached needle was immersed into the solution. The solution was drawn up into the syringe to the 3 mL mark by pulling the syringe plunger up using the probe. The probe was then pushed down to release the solution into a glass vial and was pulled up again. This procedure was repeated 15 times, and the pulling force was recorded. Results. This test shows that the syringeability of the PEO solutions is susceptible to their stress history. With increasing number of aspiration cycles, PEO solutions showed gradual decrease in drawing force, whereas the drawing force was increased for the MC solutions. Drawing force for the CMC solutions remained relatively unchanged. Conclusion. MC and CMC provide a feasible solutions to susceptibility of abuse deterrent formulations to shear stress. Atrium – Poster 39 12:15-1:15 p.m. Prescriber Perceptions of Clinical Pharmacists Within Alternative Payment Models: A Report from ACORN SEED (Accountable Care Organization Research Network, Services and Education) Diliam Jouve Gonzalez, P3, College of Pharmacy, Nova Southeastern University Hong Nguyen, P4, College of Pharmacy, Nova Southeastern University Monica Tadros, P4, College of Pharmacy, Nova Southeastern University Tina Joseph, PharmD, Assistant Professor, College of Pharmacy, Nova Southeastern University