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Kristina Aenlle, Ph.D.

Associate Director, E.M. Papper Laboratory of Clinical Immunology

Assistant Professor, K. Patel College of Osteopathic Medicine

Dr. Kristina Aenlle diverse research background has taken her from the brain to the stem cell niche of the bone, always with the focus of the endocrine system signaling and aging. Her research goal is to improve and promote healthy aging by understanding the molecular changes that are occurring duing aging. Alongside Drs. Klimas and Fltecher, she examines the molecular mechanism of HPA/HPG axis disruption in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Gulf War illness (GWI). 

Dr. Aenlle's training in endocrinology, neuroscience, aging, and biochemistry provides a strong backbone upon which she can explore the molecular and endocrine disruptions underlying ME/CFS and GWI. Her expertise contributes to the growing field of these complex, neuroinflammatory illnesses, while focusing on aging. Dr. Aenlle's long term goal is to develop a safe and efficient treatment to reboot the HPA/HPG axis and provide support during the aging process in ME/CFS and GWI. 

 

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  • A Randomized, Double-blind Placebo-controlled Phase III Trial of Coenzyme Q10 in Gulf War Illness
  • The objectives of the proposed study are to determine the efficacy and safety of ubiquinol in men and women suffering from Gulf War Illness. This study will also offer a platform for the much needed analysis of outcome variables in a well characterized longitudinal cohort; both biomarkers and clinical measures will be analyzed for their utility in future studies.
  • Measurement of Biomarkers in Samples Collected in a Coenzyme Q10 Treatment Trial in Gulf War Illness and Control Subjects
  • The primary objective is of DoD Gulf War Illness Clinical Partnership Award is to determine the efficacy of CoQ10 in GWI related symptom control.
    • Immune/Inflammatory Priming in Exacerbating Responses to GWVI Stressors: Implications for GWVI Treatments
    • The collaborative MERIT proposal hypothesizes that hyperinflammatory profiles in Gulf War Veterans could be due to exposures to chemical and/or environmental stressor and multiple vaccinations experienced by Veterans during the Gulf War, which sensitizes the affected veterans to the development of Gulf War Veterans Illness. The present project is designed in both rodent models and veterans’ cohort to test the hypothesis that chemical stressors, like insecticides and nerve gas antidotes routinely used during deployment, may induce gastrointestinal dysbiosis (gut microbiome changes) and metabolomic alterations via modulations of the gut inflammasome. These microbiome changes may lead to disruptions in barrier functions thus allowing continuous penetration of endotoxin/inflammatory mediators into the brain. These events may ultimately induce a sustained hyperinflammatory state while inflammasome blockers/probiotics may attenuate the above responses by blocking dysbiosis.

Peer-Reviewed Publications

TAp63γ and ΔNp63β Promote Osteoblastic Differentiation of Human Mesenchymal Stem Cells: Regulation by Vitamin D3 Metabolites

Curtis KM, Aenlle KK, Frisch RN, Howard GA. PLoS One. 2015 Apr 7;10(4):e0123642. doi: 10.1371/journal.pone.0123642. eCollection 2015.

 

24R,25-dihydroxyvitamin D3 Promotes the Osteoblastic Differentiation of Human Mesenchymal Stem Cells

Curtis KM, Aenlle KK, Roos BA, Howard GA. Mol Endocrinol. 2014 May;28(5):644-58. doi: 10.1210/me.2013-1241. Epub 2014 Mar 5.

 

Hepatocyte Growth Factor and p38 Promote Osteogenic Differentiation of Human Mesenchymal Stem Cells

Aenlle KK, Curtis KM, Roos BA, Howard GA. Mol Endocrinol. 2014 May;28(5):722-30. doi: 10.1210/me.2013-1286. Epub 2014 Mar 27.

 

Role of Estrogen Receptor α and β in Preserving Hippocampal Function during Aging

Han X, Aenlle KK, Bean LA, Rani A, Semple-Rowland SL, Kumar A, Foster TC. J Neurosci. 2013 Feb 6;33(6):2671-83. doi: 10.1523/JNEUROSCI.4937-12.2013.

 

Hepatocyte Growth Factor (HGF) and 1,25-dihydroxyvitamin D Together Stimulate Human Bone Marrow-derived Stem Cells Toward the Osteogenic Phenotype by HGF-induced up-regulation of VDR

Chen K, Aenlle KK, Curtis KM, Roos BA, Howard GA. Bone. 2012 Jul;51(1):69-77. doi: 10.1016/j.bone.2012.04.002. Epub 2012 Apr 12.

 

Aging Alters the Expression of Genes for Neuroprotection and Synaptic Function Following Acute Estradiol Treatment

Aenlle KK, Foster TC. Hippocampus. 2010 Sep;20(9):1047-60. doi: 10.1002/hipo.20703.

 

Estrogen Effects on Cognition and Hippocampal Transcription in Middle-aged Mice

Aenlle KK, Kumar A, Cui L, Jackson TC, Foster TC.Neurobiol Aging. 2009 Jun;30(6):932-45. Epub 2007 Oct 24.

 

Anatomy and Three-dimensional Reconstructions of the Brain of a Bottlenose Dolphin (Tursiops truncatus) from Magnetic Resonance Images

Marino L, Sudheimer KD, Murphy TL, Davis KK, Pabst DA, McLellan WA, Rilling JK, Johnson JI. Anat Rec. 2001 Dec 1;264(4):397-414. 

 

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