Nancy Klimas, M.D.

• NIH R21: Male-specific genomic mechanisms of transcriptional regulation of ME/CFS/SEID
  In an effort to provide insight into the key biological targets involved in sex-specific ME/CFS/SEID presentation, the main objective of this research proposal is to identify male-specific biomarkers and therapeutic targets of
  ME/CFS/SEID and provide insight into sex-specific disease onset and progression, which will lead to the better therapeutic intervention

• VA MERIT: Women vs. Men with GWI: Differences in Computational Models and Therapeutic Target
  We hypothesize that GWI affects regulatory function differently in women than in men, with implications on therapeutic management. The objective of this study is to improve our understanding of GWI pathogenesis in women by: (i) integrating data across several of the body’s regulatory systems, and (ii) mapping of dysfunctional signaling networks in GWI in each sex.

• NIH R01: Gender Differences in Myalgic Encepahlomyelitis/Chronic Fatigue Syndrome
  The proposed study will correct a gender imbalance in ME/CFS research. It may lead to phase 1 trials of targeted therapies designed to restore a normal balance of autonomic, immune and endocrine systems and thus, health in men and women.

• DoD CDMRR/GWIC: Brain-Immune Interactions as the Basis of Gulf War Illness: Gulf War Illness Consortium (GWIC)
  My role in the consortium is to provide core immune and genomic lab support to the investigators, and to evaluate the usefulness of biomarkers of inflammation in GWI.

• DoD CDMRP/GWIRC: Understanding Gulf War Illness: An Integrative Modeling Approach
  Integrate two animal models of GWI with human clinical data to pinpoint the underlying mechanisms of disease and target treatment more effectively to re-establish normal well-coordinated signaling interactions. Specifically, our more detailed understanding of the dysfunction associated with key metabolic pathways involved in GWI would greatly expedite the identification of promising biomarkers for improved diagnosis over the short-term as well as selection and testing of more targeted therapeutic interventions over the longer term that will address the underlying mechanisms of disease.

• VA MERIT: A Translational Medicine Approach to Gulf War Illness: From Cells to Therapy
  The objectives of the proposed study are to determine if intervening at these therapeutic targets selected via computational modeling will act as predicted and normalize immune and neuroendocrine function in an in vitro system. The study will have 2 phases: an exploration/ screening phase and a validation phase. The screening phase will be conducted on 17 repurposed drugs. These will be assessed in vitro using whole blood cultures from 40 GWI patients and 40 matched controls. The most promising 5 drugs will be validated in PBMCs from a new cohort of 40 GWI patients and 40 matched controls.

• CDC: Clinical Assessment of Patients with CFS and Biorepository Development
  Goal of project is to enable CFS researchers to provide a standardized approach to definition use in clinical diagnosis and management of CFS and improve standardization, integration, and sharing of CFS data to benefit research. Role is to oversee the clinical components of this work at our site, including the training and supervision of the clinical staff, and to assist the interdisciplinary team in the clinical utility of the findings.

• NIH R15: Genomic approach to find novel biomarkers and mechanisms of CFS/ME
  The employment of advanced genomic technologies and a well-rounded research approach will allow us to identify regulators of transcription that result in characteristic symptomatology associated with CFS/ME in female patients.

•  DoD GWIRP/ IIREA:Testing the Model: A Phase I/II Randomized Double Blind Placebo Control Trial of Therapeutics: Liposomal Glutathione and Curcumin
   The goal is to implement a phase I/II placebo control double blinded 3 arm study of liposomal glutathione, curcumin and placebo in GWI in 75 veterans with GWI (25 per arm) and assess the safety, feasibility and clinical response to the interventions;. Integrate repeat assessment and modeling of dynamic response to exercise challenge in order to map homeostatic pathways before and after 12 weeks of intervention. Finally, assess antioxidant and methylation-related metabolic status prior to, during, and after acute exercise in GWI subjects before and after these antioxidant interventions.

2019

Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness

Latimer JJ, Alhamed A, Sveiven S, Almutairy A, Klimas NG, Abreu M, Sullivan K, Grant SG. Mil Med. 2019 Jul 23. pii: usz177. doi: 10.1093/milmed/usz177.

 

Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study

Perez M, Jaundoo R, Hilton K, Del Alamo A, Gemayel K, Klimas NG, Craddock TJA, Nathanson L. Front Pediatr. 2019 May 24;7:206. doi: 10.3389/fped.2019.00206.

 

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome

Morris MC, Cooney KE, Sedghamiz H, Abreu M, Collado F, Balbin EG, Craddock TJA, Klimas NG, Broderick G, Fletcher MA. Clin Ther. 2019 Apr;41(4):656-674.e4. doi: 10.1016/j.clinthera.2019.03.002.

 

Alterations in DNA Methylation Status Associated with Gulf War Illness

Trivedi MS, Abreu MM, Sarria L, Rose N, Ahmed N, Beljanski V, Fletcher MA, Klimas NG, Nathanson L. DNA Cell Biol. 2019 Jun;38(6):561-571. doi: 10.1089/dna.2018.4469.

 

Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary

Richman S, Morris MC, Broderick G, Craddock TJA, Klimas NG, Fletcher MA. Clin Ther. 2019 May;41(5):798-805. doi: 10.1016/j.clinthera.2019.02.011.

 

Treatment Avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Split-gender Pharmacogenomic Study of Gene-expression Modules

Jeffrey MG, Nathanson L, Aenlle K, Barnes ZM, Baig M, Broderick G, Klimas NG, Fletcher MA, Craddock TJA. Clin Ther. 2019 May;41(5):815-835.e6. doi: 10.1016/j.clinthera.2019.01.011.

 

Corticosterone and Pyridostigmine/DEET Exposure Attenuate Peripheral Cytokine Expression: Supporting a Dominant Role for Neuroinflammation in a Mouse Model of Gulf War Illness

Michalovicz LT, Locker AR, Kelly KA, Miller JV, Barnes Z, Fletcher MA, Miller DB, Klimas NG, Morris M, Lasley SM, O'Callaghan JP. Neurotoxicology. 2019 Jan;70:26-32. doi: 10.1016/j.neuro.2018.10.006.

 

2018

A Logic Model of Neuronal-Glial Interaction Suggests Altered Homeostatic Regulation in the Perpetuation of Neuroinflammation

Craddock TJA, Michalovicz LT, Kelly KA, Rice MA Jr, Miller DB, Klimas NG, Morris M, O'Callaghan JP, Broderick G. Front Cell Neurosci. 2018 Oct 15;12:336. doi: 10.3389/fncel.2018.00336.

 

The Gulf War Era Cohort and Biorepository: A Longitudinal Research Resource of Veterans of the 1990-1991 Gulf War Era

Khalil L, McNeil RB, Sims KJ, Felder KA, Hauser ER, Goldstein KM, Voils CI, Klimas NG, Brophy MT, Thomas CM, Whitley RL, Dursa EK, Helmer DA, Provenzale DT. Am J Epidemiol. 2018 Nov 1;187(11):2279-2291. doi: 10.1093/aje/kwy147.

 

Identification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-associated DNA Methylation Patterns

Trivedi MS, Oltra E, Sarria L, Rose N, Beljanski V, Fletcher MA, Klimas NG, Nathanson L. PLoS One. 2018 Jul 23;13(7):e0201066. doi: 10.1371/journal.pone.0201066.

 

Insights into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Phenotypes through Comprehensive Metabolomics

Nagy-Szakal D, Barupal DK, Lee B, Che X, Williams BL, Kahn EJR, Ukaigwe JE, Bateman L, Klimas NG, Komaroff AL, Levine S, Montoya JG, Peterson DL, Levin B, Hornig M, Fiehn O, Lipkin WI. Sci Rep. 2018 Jul 3;8(1):10056. doi: 10.1038/s41598-018-28477-9.

 

Psychoneuroimmunology and Natural Killer Cells: The Chromium-Release Whole-Blood Assay

Fletcher MA, Barnes Z, Broderick G, Klimas NG. Methods Mol Biol. 2018;1781:209-220. doi: 10.1007/978-1-4939-7828-1_12.

 

Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression

Tory Toole J, Rice MA Jr, Craddock TJA, Nierenberg B, Klimas NG, Fletcher MA, Zysman J, Morris M, Broderick G. Methods Mol Biol. 2018;1781:121-144. doi: 10.1007/978-1-4939-7828-1_8.

 

Exploring the Diagnostic Potential of Immune Biomarker Co-expression in Gulf War Illness

Broderick G, Fletcher MA, Gallagher M, Barnes Z, Vernon SD, Klimas NG. Methods Mol Biol. 2018;1781:101-120. doi: 10.1007/978-1-4939-7828-1_7.

 

Increasing Resilience to Traumatic Stress: Understanding the Protective Role of Well-Being

Tory Toole J, Rice MA Jr, Cargill J, Craddock TJA, Nierenberg B, Klimas NG, Fletcher MA, Morris M, Zysman J, Broderick G. Methods Mol Biol. 2018;1781:87-100. doi: 10.1007/978-1-4939-7828-1_6. Review.

 

2017

Fecal Metagenomic Profiles in Subgroups of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Nagy-Szakal D, Williams BL, Mishra N, Che X, Lee B, Bateman L, Klimas NG, Komaroff AL, Levine S, Montoya JG, Peterson DL, Ramanan D, Jain K, Eddy ML, Hornig M, Lipkin WI. Microbiome. 2017 Apr 26;5(1):44. doi: 10.1186/s40168-017-0261-y.

 

Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study

Unger ER, Lin JS, Tian H, Natelson BH, Lange G, Vu D, Blate M, Klimas NG, Balbin EG, Bateman L, Allen A, Lapp CW, Springs W, Kogelnik AM, Phan CC, Danver J, Podell RN, Fitzpatrick T, Peterson DL, Gottschalk CG, Rajeevan MS; MCAM Study Group. Am J Epidemiol. 2017 Apr 15;185(8):617-626. doi: 10.1093/aje/kwx029.

 

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Gulf War Illness Patients Exhibit Increased Humoral Responses to the Herpesviruses-encoded dUTPase: Implications in Disease Pathophysiology

Halpin P, Williams MV, Klimas NG, Fletcher MA, Barnes Z, Ariza ME. J Med Virol. 2017 Sep;89(9):1636-1645. doi: 10.1002/jmv.24810. Epub 2017 Apr 26.

 

2016

Gastric Enterovirus Infection: A Possible Causative Etiology of Gastroparesis

Barkin JA, Czul F, Barkin JS, Klimas NG, Rey IR, Moshiree B. Dig Dis Sci. 2016 Aug;61(8):2344-50. doi: 10.1007/s10620-016-4227-x.

 

Tracking Post-Infectious Fatigue in Clinic Using Routine Lab Tests

Russell L, Broderick G, Taylor R, Fernandes H, Harvey J, Barnes Z, Smylie A, Collado F, Balbin EG, Katz BZ, Klimas NG, Fletcher MA. BMC Immunol. 2016 Mar 10;17:3. doi: 10.1186/s12865-016-0142-3.

 

Achieving Remission in Gulf War Illness: A Simulation-Based Approach to Treatment Design

Craddock TJ, Del Rosario RR, Rice M, Zysman JP, Fletcher MA, Klimas NG, Broderick G.PLoS One. 2015 Jul 20;10(7):e0132774. doi: 10.1371/journal.pone.0132774. eCollection 2015.

 

Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors 

Hall DL, Antoni MH, Lattie EG, Jutagir DR, Czaja SJ, Perdomo D, Lechner SC, Stagl JM, Bouchard LC, Gudenkauf LM, Traeger L, Fletcher M, Klimas NG. Fatigue. 2015;3(3):142-155.

 

Using Gene Expression Signatures to Identify Novel Treatment Strategies in Gulf War Illness

Craddock TJ, Harvey JM, Nathanson L, Barnes ZM, Klimas NG, Fletcher MA, Broderick G. BMC Med Genomics. 2015 Jul 9;8:36. doi: 10.1186/s12920-015-0111-3.

 

Inferring Broad Regulatory Biology from Time Course Data: Have We Reached an Upper Bound Under Constraints Typical of In Vivo Studies? 

Vashishtha S, Broderick G, Craddock TJ, Fletcher MA, Klimas NG. PLoS One. 2015 May 18;10(5):e0127364. doi: 10.1371/journal.pone.0127364. eCollection 2015.

 

Distinct Plasma Immune Signatures in ME/CFS are Present Early in the Course Of Illness

Hornig M, Montoya JG, Klimas NG, Levine S, Felsenstein D, Bateman L, Peterson DL, Gottschalk CG, Schultz AF, Che X, Eddy ML, Komaroff AL, Lipkin WI. Sci Adv. 2015 Feb;1(1). pii: e1400121.

 

2014

No Association Found Between the Detection of Either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus and Chronic Fatigue Syndrome in a Blinded, Multi-Site, Prospective Study by the Establishment and Use of the SolveCFS BioBank.

Irlbeck DM, Vernon SD, McCleary KK, Bateman L, Klimas NG, Lapp CW, Peterson DL, Brown JR, Remlinger KS, Wilfret DA, Gerondelis P. BMC Res Notes. 2014 Aug 4;7:461. doi: 10.1186/1756-0500-7-461.

 

Stress Management Skills, Cortisol Awakening Response, and Post-Exertional Malaise in Chronic Fatigue Syndrome

Hall DL, Lattie EG, Antoni MH, Fletcher MA, Czaja S, Perdomo D, Klimas NG. Psychoneuroendocrinology. 2014 Nov;49:26-31. doi: 10.1016/j.psyneuen.2014.06.021. Epub 2014 Jul 6.

 

A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome

Craddock TJ, Fritsch P, Rice MA Jr, del Rosario RM, Miller DB, Fletcher MA, Klimas NG, Broderick G. PLoS One. 2014 Jan 8;9(1):e84839. doi: 10.1371/journal.pone.0084839. eCollection 2014. Erratum in: PLoS One. 2014;9(4):e94161. PLoS One. 2014;9(6):e100355.

 

2013

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden

Lattie, E.G., Antoni, M.H., Fletcher, M.A., Czaja, S., Perdomo, D., Sala, A., Nair, S., Fu, S.H., Penedo, F.J., Klimas, N. Fatigue. 2013;1(4). doi: 10.1080/21641846.2013.843255.

 

A Comparison of Sex-Specific Immune Signatures in Gulf War Illness and Chronic Fatigue Syndrome

Smylie, A.L., Broderick, G., Fernandes, H., Razdan, S., Barnes, Z., Collado, F., Sol, C., Fletcher, M.A., Klimas, N. BMC Immunol. 2013 Jun 25;14:29. doi: 10.1186/1471-2172-14-29.

 

Altered Immune Pathway Activity Under Exercise Challenge in Gulf War Illness: An Exploratory Analysis

Broderick, G., Ben-Hamo, R., Vashishtha, S., Efroni, S., Nathanson, L., Barnes, Z., Fletcher, M.A., Klimas, N. Brain Behav Immun. 2013 Feb;28:159-69. doi: 10.1016/j.bbi.2012.11.007.

 

2012

A Multicenter Blinded Analysis Indicates No Association Between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

Alter, H.J., Mikovits, J.A., Switzer, W.M., Ruscetti, F.W., Lo, S.C., Klimas, N., Komaroff, A.L., Montoya, J.G., Bateman, L., Levine, S., Peterson, D., Levin, B., Hanson, M.R., Genfi, A., Bhat, M., Zheng, H., Wang, R., Li, B., Hung, G.C., Lee, L.L., Sameroff, S., Heneine, W., Coffin, J., Hornig, M., Lipkin, W.I. MBio. 2012 Sep 18;3(5). pii: e00266-12. doi: 10.1128/mBio.00266-12.

 

Cytokine Expression Profiles of Immune Imbalance in Post-Mononucleosis Chronic Fatigue

Broderick, G., Katz, B.Z., Fernandes, H., Fletcher, M.A., Klimas, N., Smith, F.A., O'Gorman, M.R., Vernon, S.D., Taylor, R. J Transl Med. 2012 Sep 13;10:191. doi: 10.1186/1479-5876-10-191.

 

Psychoneuroimmunology and Natural Killer Cells: The Chromium Release Whole Blood Assay

Fletcher MA, Barnes Z, Broderick G, Klimas NG. Methods Mol Biol. 2012;934:313-24. doi: 10.1007/978-1-62703-071-7_16.

 

Exploring the Diagnostic Potential of Immune Biomarker Coexpression in Gulf War Illness

Broderick G, Fletcher MA, Gallagher M, Barnes Z, Vernon SD, Klimas NG. Methods Mol Biol. 2012;934:145-64. doi: 10.1007/978-1-62703-071-7_8.

 

Biomarkers for Chronic Fatigue

Klimas NG, Broderick G, Fletcher MA. Brain Behav Immun. 2012 Nov;26(8):1202-10. doi: 10.1016/j.bbi.2012.06.006.

 

Stress Management Skills, Neuroimmune Processes and Fatigue Levels in Persons with Chronic Fatigue Syndrome

Lattie, E.G., Antoni, M.H., Fletcher, M.A., Penedo, F., Czaja, S., Lopez, C., Perdomo, D., Sala, A., Nair, S., Fu, S.H., Klimas, N. Brain Behav Immun. 2012 Aug;26(6):849-58. doi: 10.1016/j.bbi.2012.02.008.

 

Minimum Data Elements for Research Reports on CFS

Jason, L.A., Unger, E.R., Dimitrakoff, J.D., Fagin, A.P., Houghton, M., Cook, D.B., Marshall, G.D. Jr., Klimas, N., Snell, C. Brain Behav Immun. 2012 Mar;26(3):401-6. doi: 10.1016/j.bbi.2012.01.014.

 

2011

Myalgic Encephalomyelitis: International Consensus Criteria

Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles AC, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell DS, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall-Gradisnik S, Mena I, Mikovits JA, Miwa K, Murovska M, Pall ML, Stevens S. J Intern Med. 2011 Oct;270(4):327-38. doi: 10.1111/j.1365-2796.2011.02428.x.

 

Immunological Abnormalities as Potential Biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis 

Brenu EW, van Driel ML, Staines DR, Ashton KJ, Ramos SB, Keane J, Klimas NG, Marshall-Gradisnik SM. J Transl Med. 2011 May 28;9:81. doi: 10.1186/1479-5876-9-81.

 

A Pilot Study of Cognitive Behavioral Stress Management Effects on Stress, Quality of Life, and Symptoms in Persons with Chronic Fatigue Syndrome

Lopez, C., Antoni, M., Penedo, F., Weiss, D., Cruess, S., Segotas, M.C., Helder, L., Siegel, S., Klimas, N., Fletcher, M.A. J Psychosom Res. 2011 Apr;70(4):328-34. doi: 10.1016/j.jpsychores.2010.11.010.

 

Stress Buffering Effects of Oxytocin on HIV Status in Low-Income Ethnic Minority Women

Fekete, E.M., Antoni, M.H., Lopez, C., Mendez, A.J., Szeto, A., Fletcher, M.A., Klimas, N., Kumar, M., Schneiderman, N. Psychoneuroendocrinology. 2011 Jul;36(6):881-90. doi: 10.1016/j.psyneuen.2010.12.003.

 

A Pilot Study of Immune Network Remodeling Under Challenge in Gulf War Illness

Broderick, G., Kreitz, A., Fuite, J., Fletcher, M.A., Vernon, S.D., Klimas, N. Brain Behav Immun. 2011 Feb;25(2):302-13. doi: 10.1016/j.bbi.2010.10.011.

 

2010

Plasma Neuropeptide Y: A Biomarker for Symptom Severity in Chronic Fatigue Syndrome

Fletcher, M.A., Rosenthal, M., Antoni, M., Ironson, G., Zeng, X.R., Barnes, Z., Harvey, J.M., Hurwitz, B., Levis, S., Broderick, G., Klimas, N.G. Behav Brain Funct. 2010 Dec 29;6:76. doi: 10.1186/1744-9081-6-76.

 

Long-Term Safety of Testosterone and Growth Hormone Supplementation: A Retrospective Study of Metabolic, Cardiovascular, and Oncologic Outcomes

Ginzburg, E., Klimas, N., Parvus, C., Life, J., Willix, R., Barber, M.J., Lin, A., Comite, F. J Clin Med Res. 2010 Aug 18;2(4):159-66. doi: 10.4021/jocmr428w.

 

Biomarkers in Chronic Fatigue Syndrome: Evaluation of Natural Killer Cell Function and Dipeptidyl Peptidase IV/CD26

Fletcher, M.A., Zeng, X.R., Maher, K., Levis, S., Hurwitz, B., Antoni, M., Broderick, G., Klimas, N.G. PLoS One. 2010 May 25;5(5):e10817. doi: 10.1371/journal.pone.0010817.

A Formal Analysis of Cytokine Networks in Chronic Fatigue Syndrome

Broderick, G., Fuite, J., Kreitz, A., Vernon, S.D., Klimas, N., Fletcher, M.A. Brain Behav Immun. 2010 Oct;24(7):1209-17. doi: 10.1016/j.bbi.2010.04.012.

 

2009

Plasma Cytokines in Women with Chronic Fatigue Syndrome

Fletcher, M.A., Zeng, X.R., Barnes, Z., Levis, S., Klimas, N.G. J Transl Med. 2009 Nov 12;7:96. doi: 10.1186/1479-5876-7-96.

Men's Serostatus Disclosure to Parents: Associations Among Social Support, Ethnicity, and Disease Status in Men Living with HIV

Fekete, E.M., Antoni, M.H., Lopez, C.R., Durán, R.E., Penedo, F.J., Bandiera, F.C., Fletcher, M.A., Klimas, N., Kumar, M., Schneiderman, N. Brain Behav Immun. 2009 Jul;23(5):693-9. doi: 10.1016/j.bbi.2009.01.007.

Chronic Fatigue Syndrome: Illness Severity, Sedentary Lifestyle, Blood Volume and Evidence of Diminished Cardiac Function

Hurwitz, B.E., Coryell, V.T., Parker, M., Martin, P., Laperriere, A., Klimas, N.G., Sfakianakis, G.N., Bilsker, M.S. Clin Sci (Lond). 2009 Oct 19;118(2):125-35. doi: 10.1042/CS20090055.

Impaired Immune Function in Gulf War Illness

Whistler, T., Fletcher, M.A., Lonergan, W., Zeng, X.R., Lin, J.M., Laperriere, A., Vernon, S.D., Klimas, N.G. BMC Med Genomics. 2009 Mar 5;2:12. doi: 10.1186/1755-8794-2-12.

 

2008

Overview of HIV

Klimas, N., Koneru, A.O., Fletcher, M.A. Psychosom Med. 2008 Jun;70(5):523-30. doi: 10.1097/PSY.0b013e31817ae69f.

 

Psychological Distress, Killer Lymphocytes And Disease Severity in HIV/AIDS

Greeson, J.M., Hurwitz, B.E., Llabre, M.M., Schneiderman, N., Penedo, F.J., Klimas, N.G. Brain Behav Immun. 2008 Aug;22(6):901-11. doi: 10.1016/j.bbi.2008.01.001.

 

Testosterone and Growth Hormone Normalization: A Retrospective Study of Health Outcomes

Ginzburg, E., Lin, A., Sigler, M., Olsen, D., Klimas, N., Mintz, A. J Multidiscip Healthc. 2008 Sep 1;1:79-86.

 

2007

Chronic Fatigue Syndrome: Inflammation, Immune Function, and Neuroendocrine Interactions

Klimas, N.G., Koneru, A.O. Curr Rheumatol Rep. 2007 Dec;9(6):482-7.

 

Fatigue: Case Definition and Guidelines for Collection, Analysis, and Presentation of Immunization Safety Data

Jones, J.F., Kohl, K.S., Ahmadipour, N., Bleijenberg, G., Buchwald, D., Evengard, B., Jason, L.A., Klimas, N.G., Lloyd, A., McCleary, K., Oleske, J.M., White, P.D. Vaccine. 2007 Aug 1;25(31):5685-96. Epub 2007 Mar 12.

 

Predictors of CD4 Count Change Over 8 Months of Follow Up in HIV-1-Infected Patients with a CD4 Count>or=300 cells/microL Who Were Assigned to 7.5 MIU Interleukin-2

ESPRIT Research Group, Fox, Z., Antunes, F., Davey, R., Gazzard, B., Klimas, N., Labriola, A., Losso, M., Neaton, J.D., Phillips, A.N., Ruxrungtham, K., Staszewski, S., Weiss, L., Lundgren, J.D. HIV Med. 2007 Mar;8(2):112-23.

 

2006

Spouses of Persian Gulf War I Veterans: Medical Evaluation of a U.S. Cohort

Eisen, S.A., Karlinsky, J., Jackson, L.W., Blanchard, M., Kang, H.K., Murphy, F.M., Alpern, R., Reda, D.J., Toomey, R., Battistone, M.J., Parks, B.J., Klimas, N., Pak, H.S., Hunter, J., Lyons, M.J., Henderson, W.G. Mil Med. 2006 Jul;171(7):613-8.

 

Social Support Mediates Loneliness and Human Herpesvirus Type 6 (HHV-6) Antibody Titers

Dixon, D., Cruess, S., Kilbourn, K., Klimas, N., Fletcher, M.A., Ironson, G., Baum, A., Schneiderman, N., Antoni, M.H. Health Psychol. 2004 Jul;23(4):413-418. doi: 10.1037/0278-6133.23.4.413.

 

Impaired Natural Immunity, Cognitive Dysfunction, and Physical Symptoms in Patients with Chronic Fatigue Syndrome: Preliminary Evidence for a Subgroup?

Siegel, S.D., Antoni, M.H., Fletcher, M.A., Maher, K., Segota, M.C., Klimas, N. J Psychosom Res. 2006 Jun;60(6):559-66.

 

Exploration of Statistical Dependence Between Illness Parameters Using the Entropy Correlation Coefficient

Craddock, R.C., Taylor, R., Broderick, G., Whistler, T., Klimas, N., Unger, E.R. Pharmacogenomics. 2006 Apr;7(3):421-8.

 

Identifying Illness Parameters in Fatiguing Syndromes Using Classical Projection Methods

Broderick, G., Craddock, R.C., Whistler, T., Taylor, R., Klimas, N., Unger, E.R. Pharmacogenomics. 2006 Apr;7(3):407-19.

 

Gene Expression Correlates of Unexplained Fatigue

Whistler, T., Taylor, R., Craddock, R.C., Broderick, G., Klimas, N., Unger, E.R. Pharmacogenomics. 2006 Apr;7(3):395-405.

 

Reductions in Depressed Mood and Denial Coping During Cognitive Behavioral Stress Management with HIV-Positive Gay Men Treated with HAART

Carrico, A.W., Antoni, M.H., Duran, R.E., Ironson, G., Penedo, F., Fletcher, M.A., Klimas, N., Schneiderman, N. Ann Behav Med. 2006 Apr;31(2):155-64.

 

Randomized Clinical Trial of Cognitive Behavioral Stress Management on Human Immunodeficiency Virus Viral Load in Gay Men Treated with Highly Active Antiretroviral Therapy

Antoni, M.H., Carrico, A.W., Durán, R.E., Spitzer, S., Penedo, F., Ironson, G., Fletcher, M.A., Klimas, N., Schneiderman, N. Psychosom Med. 2006 Jan-Feb;68(1):143-51.

 

2005

Psychosocial Factors Predict CD4 And Viral Load Change in Men and Women with Human Immunodeficiency Virus in the Era of Highly Active Antiretroviral Treatment

Ironson, G., O'Cleirigh, C., Fletcher, M.A., Laurenceau, J.P., Balbin, E., Klimas, N., Schneiderman, N., Solomon, G. Psychosom Med. 2005 Nov-Dec;67(6):1013-21.

 

Cognitive Behavioral Stress Management Effects on Mood, Social Support, and a Marker of Antiviral Immunity are Maintained Up to 1 Year in HIV-infected Gay Men

Carrico, A.W., Antoni, M.H., Pereira, D.B., Fletcher, M.A., Klimas, N., Lechner, S.C., Schneiderman, N. Int J Behav Med. 2005;12(4):218-26.

Sympathoimmune Anomalies Underlying the Response to Stressful Challenge in Human Immunodeficiency Virus Spectrum Disease

Hurwitz, B.E., Brownley, K.A., Motivala, S.J., Milanovich, J.R., Kibler, J.L., Fillion, L., LeBlanc, W.G., Kumar, M., Klimas, N.G., Fletcher, M.A., Schneiderman, N. Psychosom Med. 2005 Sep-Oct;67(5):798-806.

Gulf War Veterans' Health: Medical Evaluation of a U.S. Cohort

Eisen, S.A., Kang, H.K., Murphy, F.M., Blanchard, M.S., Reda, D.J., Henderson, W.G., Toomey, R., Jackson, L.W., Alpern, R., Parks, B.J., Klimas, N., Hall, C., Pak, H.S., Hunter, J., Karlinsky, J., Battistone, M.J., Lyons, M.J. Ann Intern Med. 2005 Jun 7;142(11):881-90.

Increases in a Marker of Immune System Reconstitution are Predated by Decreases in 24-h Urinary Cortisol Output and Depressed Mood During a 10-Week Stress Management Intervention in Symptomatic HIV-infected Men

Antoni, M.H., Cruess, D.G., Klimas, N., Carrico, A.W., Maher, K., Cruess, S., Lechner, S.C., Kumar, M., Lutgendorf, S., Ironson, G., Fletcher, M.A., Schneiderman, N. J Psychosom Res. 2005 Jan;58(1):3-13.

Stress-Associated Changes in the Steady-State Expression of Latent Epstein-Barr Virus: Implications for Chronic Fatigue Syndrome and Cancer

Glaser, R., Padgett, D.A., Litsky, M.L., Baiocchi, R.A., Yang, E.V., Chen, M., Yeh, P.E., Klimas, N.G., Marshall, G.D., Whiteside, T., Herberman, R., Kiecolt-Glaser, J., Williams, M.V. Brain Behav Immun. 2005 Mar;19(2):91-103.

Development and Implementation of a Medication Adherence Training Instrument for Persons Living with HIV: The MATI

McPherson-Baker, S., Jones, D., Durán, R.E., Klimas, N., Schneiderman, N. Behav Modif. 2005 Mar;29(2):286-317.