Effect of EnChroma Lens on Spectral Sensitivity of the Retina in CVD

Grant Winners

  • David Loshin, O.D., Ph.D., FAAO – College of Optometry
  • Hua Bi, O.D., Ph.D. – College of Optometry
  • Jill Wallace-Ross, D.O. – College of Osteopathic Medicine
  • Prajakta Joshi, B.S. – College of Osteopathic Medicine


  • David Loshin, O.D., Ph.D., FAAO – College of Optometry
  • Elaine Wallace, D.O., M.S., M.S., M.S – College of Osteopathic Medicine


Award Winners Color vision deficiency (CVD) is the inability to distinguish certain shades of color or in more severe cases, see colors at all. These color deficiencies can be either inherited or acquired. Congenital CVD results from gene mutations for visual pigment of cones in the retina. Acquired color deficiencies occur after birth and derive from a disorder affecting the visual pathway. CVD can seriously affect an individual's ability to learn, to work at a chosen occupation and recognize traffic signs while driving. Compared to conventional color-tinted lenses that enhance color vision by emphasizing one color at the expense of others, the new EnChroma Cx-65 Lens uses a narrow-band notch filter in order to better separate the responses of different cones with overlapping absorption curves. In this proposed study, spectral sensitivity of different cones with overlapping absorption curves at the retinal level will be measured and compared using chromatic ERG testing in 30 subjects with color vision deficiency with and without the EnChroma Cx-65 Lens. The results of this study will not only provide valuable information on the mechanism of distinguishing responses from cones with overlapping absorption curves by the narrow-band notch filter, but also provide important direction for future lens design to improve color perception in CVD patients.